Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Periodically tailored titania nanotubes for enhanced drug loading and releasing performances|
|Citation:||Journal of Materials Chemistry B, 2015; 3(12):2553-2559|
|Publisher:||Royal Society of Chemistry|
|Karan Gulati, Krishna Kant, David Findlay and Dusan Losic|
|Abstract:||The structural engineering of titania nanotubes (TNTs) using electrochemical anodization was performed to generate periodically modulated (p-TNTs) internal structures by applying an oscillatory voltage during the anodization process to demonstrate their improved drug-loading and drug-releasing properties. Drug loading and in vitro drug release studies compared with conventional TNTs with flat structures suggested considerable improvement with increased drug loading, reduced burst release and extended drug release for over 2 weeks. Furthermore, p-TNTs arrays were fractured by ultrasonication into liberated TNTs capsules and their potential applications as drug micro/nano-carriers for targeted and localized drug delivery is proposed. The presented electrochemical approach for structural engineering of TNTs provides new prospects in designing TNTs drug releasing implants with advanced drug-loading/release characteristics for localized drug delivery. Such implant modifications can further be tailored to cater for various implant challenges and bone therapies like: inflammation, infection and poor implant integration.|
|Description:||First published online 18 Feb 2015|
|Rights:||This journal is © The Royal Society of Chemistry 2015|
|Appears in Collections:||IPAS publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.