Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen|
|Citation:||American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000; 279(1 42-1):G157-G162|
|Publisher:||Amer Physiological Soc|
|Abstract:||Activation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABA(B) receptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. We aimed to determine first whether this effect of baclofen is maintained at high-level distention and second the role of splanchnic pathways in triggering TLESR. Micromanometric/pH studies in conscious ferrets showed that intragastric glucose infusion (25 ml) increased triggering of TLESR and reflux. Both were significantly reduced by baclofen (7 micromol/kg ip) (P < 0.05). When 40 ml of air was added to the glucose infusion, more TLESR occurred than with glucose alone (P < 0.01). These were also reduced by baclofen (P < 0.001). TLESR after glucose/air infusion were assessed before and after splanchnectomy (2-4, 9-11, and 23-25 days), which revealed no change. Baclofen inhibits TLESR after both low- and high-level gastric distention. Splanchnic pathways do not contribute to increased triggering of TLESR by high-level gastric distention.|
|Keywords:||Muscle, Smooth; Esophagogastric Junction; Splanchnic Nerves; Animals; Ferrets; Gastroesophageal Reflux; Baclofen; Capsaicin; Glucose; Receptors, GABA-B; Muscle Relaxants, Central; Muscle Denervation; Eating; Pressure; Female|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.