Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9247
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Type: Journal article
Title: Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly
Author: Beckoff, K.
MacIntosh, C.
Chapman, I.
Wishart, J.
Morris, H.
Horowitz, M.
Jones, K.
Citation: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2001; 280(2):R570-R576
Publisher: Amer Physiological Soc
Issue Date: 2001
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Katherine Beckoff, Caroline G. MacIntosh, Ian M. Chapman, Judith M. Wishart, Howard A. Morris, Michael Horowitz, and Karen L. Jones
Abstract: The aims of this study were to evaluate the effects of dietary glucose supplementation on gastric emptying (GE) of both glucose and fat, postprandial blood glucose homeostasis, and appetite in eight older subjects (4 males, 4 females, aged 65–84 yr). GE of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the GE study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). Glucose supplementation accelerated GE of glucose (P , 0.05), but not oil; there was a trend for an increase in GIP (at 15 min, P 5 0.06), no change in GLP-1, an earlier insulin peak (P , 0.01), and a subsequent reduction in blood glucose (at 75 min, P , 0.01). Glucose supplementation had no effect on food intake during each diet so that energy intake was greater (P , 0.001) during the glucose-supplemented diet. Appetite ratings and energy intake at the buffet meal were not different. We conclude that, in older subjects, glucose supplementation 1) accelerates GE of glucose, but not fat; 2) modifies postprandial blood glucose homeostasis; and 3) increases energy intake.
Keywords: anorexia of aging; insulin; gastric inhibitory polypeptide; glucagon-like peptide-1; satiety
Description: Published abstract used with permission of the copyright owner.
Rights: Copyright © 2001 American Physiological Society
RMID: 0020011043
DOI: 10.1152/ajpregu.2001.280.2.r570
Published version: http://ajpregu.physiology.org/cgi/content/abstract/280/2/R570
Appears in Collections:Medicine publications

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