Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/92487
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLaw, C.-
dc.contributor.authorSantos, A.-
dc.contributor.authorKumeria, T.-
dc.contributor.authorLosic, D.-
dc.date.issued2015-
dc.identifier.citationACS Applied Materials and Interfaces, 2015; 7(6):3846-3853-
dc.identifier.issn1944-8244-
dc.identifier.issn1944-8252-
dc.identifier.urihttp://hdl.handle.net/2440/92487-
dc.descriptionPublication Date (Web): January 27, 2015-
dc.description.abstractIn this study, we present a nanoengineered therapeutic-releasing system based on aluminum wires featuring nanoporous anodic alumina layers and chitosan coatings. Nanoporous anodic alumina layers are produced on the surface of aluminum wires by electrochemical anodization. These nanoporous layers with precisely engineered nanopore geometry are used as nanocontainers for bovine serum albumin molecules labeled with fluorescein isothiocyanate (BSA-FITC), which is selected as a model drug. The surface of these therapeutic-releasing implants is coated with a biocompatible and biodegradable polymer, chitosan, in order to achieve a sustained release of protein over extended periods of time. The performance of this therapeutic-releasing device is systematically assessed through a series of experiments under static and dynamic flow conditions. In these experiments, the effect of such parameters as the number of layers of chitosan coating and the temperature and pH of the eluting medium is established. The obtained results reveal that the proposed therapeutic-releasing system based on nanoporous aluminum wires can be engineered with sustained release performance for up to 6.5 weeks, which is a critical factor for medical treatments using sensitive therapeutics such as proteins and genes when a localized delivery is desired.-
dc.description.statementofresponsibilityCheryl Suwen Law, Abel Santos, Tushar Kumeria, and Dusan Losic-
dc.language.isoen-
dc.publisherAmerican Chemical Society-
dc.rights© 2015 American Chemical Society-
dc.subjectaluminum wires; therapeutic release; nanoporous anodic alumina; chitosan coatings; simulated body conditions-
dc.titleEngineered therapeutic-releasing nanoporous anodic alumina-aluminum wires with extended release of therapeutics-
dc.typeJournal article-
dc.identifier.doi10.1021/am5091963-
dc.relation.granthttp://purl.org/au-research/grants/arc/DE140100549-
dc.relation.granthttp://purl.org/au-research/grants/arc/DP120101680-
dc.relation.granthttp://purl.org/au-research/grants/arc/FT110100711-
pubs.publication-statusPublished-
dc.identifier.orcidLaw, C. [0000-0002-3276-8052]-
dc.identifier.orcidSantos, A. [0000-0002-5081-5684]-
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]-
Appears in Collections:Aurora harvest 7
IPAS publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.