Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/92541
Type: Thesis
Title: Comparative outcomes of craniectomy versus cranial remodelling in the human infant with isolated sagittal synostosis.
Author: Thwin, May
Issue Date: 2015
School/Discipline: School of Translational Health Science
Abstract: BACKGROUND Craniosynostosis is a congenital condition characterised by the premature closure of one or more cranial sutures. The sagittal suture is the most common site, comprising 40-60% of cases. Premature fusion of this suture can cause scaphocephaly, seen morphologically as a narrow elongated skull with a decreased cephalic index. Diagnosis is made clinically and/or radiologically. The goals of surgical correction and the techniques used have evolved over time. Whilst there has been a general move from limited craniectomy to calvarial remodelling, in recent times there has been a return towards less invasive methods. OBJECTIVES The objectives were to identify and synthesize the best available evidence on the morphological, functional and neurological outcomes of craniectomy compared to cranial vault remodelling and compare this to existing results. METHODS A systematic review of the literature was conducted using the Joanna Briggs Institute methodology. The review considered studies of infants with primary isolated sagittal synostosis operated on before a mean of two years of age. The intervention of interest was sagittal craniectomy; this was compared to cranial vault remodelling. Morphological, functional and neurological outcomes were included. Mortality, complications and aesthetic outcome were included as tertiary outcomes. A comprehensive search was undertaken across major databases. Retrieved studies were assessed by two independent reviewers for methodological validity. Data was extracted and where possible, pooled in statistical meta-analysis. Where this was not possible, findings were presented in narrative form. RESULTS Based on critical appraisal 27 studies, all descriptive in nature, were of suitable quality for inclusion. Meta-analysis was only possible for the primary morphological outcome (mean change in cephalic index post-operatively) based on two studies. This showed that at one year post-operative follow-up remodelling offers an advantage over craniectomy (Z = 4.16, P<0.0001). Narrative synthesis suggests that improvements of cephalic index to varying degrees were seen in patients receiving either procedure; whilst the mean change appears to peak early in patients who have undergone remodelling procedures, the trend suggests it may improve in the longer term after craniectomy. Whilst global IQ scores may be comparable to an age-matched population, narrative review suggests that patients with sagittal synostosis who have undergone a surgical correction of any type may have discrepancies in specific domains and may be at risk of developing learning disorders. There is insufficient primary research with inter-procedure comparison of pre-operative and post-operative cognitive or neurological outcome. CONCLUSIONS At one year follow-up, remodelling is superior to craniectomy in terms of mean change in cephalic index. However both procedures were seen to give improvements in the short, medium and long term. Neither procedure offers a distinct sustained advantage; longer follow-up is required to assess the comparative improvement over time. There is insufficient evidence whether craniectomy or remodelling procedures offer superior functional or neurological outcome. Patients who have had surgical repair (any type) may have deficiencies in different subdomains and be at risk of learning disorders, whilst maintaining an age-appropriate global IQ and school performance. It is unknown if either surgery impart any restorative or protective benefit.
Advisor: Schultz, Timothy John
Anderson, Peter John
Dissertation Note: Thesis (M.Clin.Sc.) -- University of Adelaide, School of Translational Health Science, 2015
Keywords: craniosynostosis; sagittal synostosis; craniectomy; suturectomy; cranial vault remodelling
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
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