Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/92564
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heruc, G. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Deacon, C. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Luscombe-Marsh, N. | - |
dc.contributor.author | Little, T. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | American Journal of Physiology: Endocrinology and Metabolism, 2014; 307(9):E830-E837 | - |
dc.identifier.issn | 0193-1849 | - |
dc.identifier.issn | 1522-1555 | - |
dc.identifier.uri | http://hdl.handle.net/2440/92564 | - |
dc.description | Published 1 November 2014 | - |
dc.description.abstract | Fat is the most potent stimulus for glucagon-like peptide-1 (GLP-1) secretion. The aims of this study were to determine whether dipeptidyl peptidase IV (DPP-IV) inhibition would enhance plasma active incretin [glucose-dependent insulinotropic polypeptide (GIP), GLP-1] concentrations and modulate the glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to intraduodenal fat infusion. In a double-blind, randomized, placebo-controlled crossover design, 16 healthy lean males received 50 mg vildagliptin (V), or matched placebo (P), before intraduodenal fat infusion (2 kcal/min, 120 min). Blood glucose, plasma insulin, glucagon, active GLP-1, and GIP and peptide YY (PYY)-(3-36) concentrations; resting energy expenditure; and energy intake at a subsequent buffet meal (time = 120-150 min) were quantified. Data are presented as areas under the curve (0-120 min, means ± SE). Vildagliptin decreased glycemia (P: 598 ± 8 vs. V: 573 ± 9 mmol·l⁻¹·min⁻¹, P < 0.05) during intraduodenal lipid. This was associated with increased insulin (P: 15,964 ± 1,193 vs. V: 18,243 ± 1,257 pmol·l⁻¹·min⁻¹, P < 0.05), reduced glucagon (P: 1,008 ± 52 vs. V: 902 ± 46 pmol·l⁻¹·min⁻¹, P < 0.05), enhanced active GLP-1 (P: 294 ± 40 vs. V: 694 ± 78 pmol·l⁻¹·min⁻¹) and GIP (P: 2,748 ± 77 vs. V: 4,256 ± 157 pmol·l⁻¹·min⁻¹), and reduced PYY-(3-36) (P: 9,527 ± 754 vs. V: 4,469 ± 431 pM/min) concentrations compared with placebo (P < 0.05, for all). Vildagliptin increased resting energy expenditure (P: 1,821 ± 54 vs. V: 1,896 ± 65 kcal/day, P < 0.05) without effecting energy intake. Vildagliptin 1) modulates the effects of intraduodenal fat to enhance active GLP-1 and GIP, stimulate insulin, and suppress glucagon, thereby reducing glycemia and 2) increases energy expenditure. These observations suggest that the fat content of a meal, by enhancing GLP-1 and GIP secretion, may contribute to the response to DPP-IV inhibition. | - |
dc.description.statementofresponsibility | Gabriella A. Heruc, Michael Horowitz, Carolyn F. Deacon, Christine Feinle-Bisset, Christopher K. Rayner, Natalie Luscombe-Marsh, and Tanya J. Little | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 2014 the American Physiological Society | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpendo.00370.2014 | - |
dc.subject | gastrointestinal hormones; glucose; metabolism | - |
dc.title | Effects of dipeptidyl peptidase IV inhibition on glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to fat in healthy males | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpendo.00370.2014 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1022706 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627002 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627118 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Heruc, G. [0000-0002-6257-6828] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Luscombe-Marsh, N. [0000-0001-9690-4722] | - |
dc.identifier.orcid | Little, T. [0000-0001-9814-1036] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.