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Type: Journal article
Title: Gastrointestinal mucositis: the role of MMP-tight junction interactions in tissue injury
Author: Al-Dasooqi, N.
Wardill, H.
Gibson, R.
Citation: Pathology and Oncology Research, 2014; 20(3):485-491
Publisher: Springer Netherlands
Issue Date: 2014
ISSN: 1219-4956
Statement of
Noor Al-Dasooqi, Hannah R. Wardill, Rachel J Gibson
Abstract: Chemotherapy for cancer causes significant gut toxicity known as mucositis. The pathogenesis of mucositis is ill defined. Recent clinical research guidelines have highlighted epithelial junctional complexes as emerging targets within mucositis research. Given the robust biological evidence linking tight junctions and matrix metalloproteinases, key mediators of mucositis, tight junction proteins have received significant attention. Despite this, the link between tight junctions, matrix metalloproteinases and mucositis development is yet to be established. This critical review therefore aims to describe the role of matrix metalloproteinases in mucositis, and how matrix metalloproteinase-dependent tight junction disruption may contribute to the pathobiology of mucositis.
Keywords: Matrix metalloproteinases; Tight junctions; Gut toxicity, Mucositis, Chemotherapy
Rights: © Arányi Lajos Foundation 2014
RMID: 0030010721
DOI: 10.1007/s12253-013-9733-y
Appears in Collections:Anatomical Sciences publications

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