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Type: Journal article
Title: Scaling of left ventricle cardiomyocyte ultrastructure across development in the kangaroo Macropus fuliginosus
Author: Snelling, E.
Taggart, D.
Maloney, S.
Farrell, A.
Leigh, C.
Waterhouse, L.
Williams, R.
Seymour, R.
Citation: The Journal of Experimental Biology, 2015; 218(11):1767-1776
Publisher: The Company of Biologists
Issue Date: 2015
ISSN: 0022-0949
Statement of
Edward P. Snelling, David A. Taggart, Shane K. Maloney, Anthony P. Farrell, Christopher M. Leigh, Lyn Waterhouse, Ruth Williams, and Roger S. Seymour
Abstract: The heart and left ventricle of the marsupial western grey kangaroo Macropus fuliginosus exhibit biphasic allometric growth, whereby a negative shift in the trajectory of cardiac growth occurs at pouch exit. In this study, we used transmission electron microscopy to examine the scaling of left ventricle cardiomyocyte ultrastructure across development in the western grey kangaroo over a 190-fold body mass range (0.355-67.5 kg). The volume-density (%) of myofibrils, mitochondria, sarcoplasmic reticuli and T-tubules increase significantly during in-pouch growth, such that the absolute volume (ml) of these organelles scales with body mass (Mb; kg) with steep hyperallometry: 1.41Mb (1.38), 0.64Mb (1.29), 0.066Mb (1.45) and 0.035Mb (1.87), respectively. Maturation of the left ventricle ultrastructure coincides with pouch vacation, as organelle volume-densities scale independent of body mass across post-pouch development, such that absolute organelle volumes scale in parallel and with relatively shallow hypoallometry: 4.65Mb (0.79), 1.75Mb (0.77), 0.21Mb (0.79) and 0.35Mb (0.79), respectively. The steep hyperallometry of organelle volumes and volume-densities across in-pouch growth is consistent with the improved contractile performance of isolated cardiac muscle during fetal development in placental mammals, and is probably critical in augmenting cardiac output to levels necessary for endothermy and independent locomotion in the young kangaroo as it prepares for pouch exit. The shallow hypoallometry of organelle volumes during post-pouch growth suggests a decrease in relative cardiac requirements as body mass increases in free-roaming kangaroos, which is possibly because the energy required for hopping is independent of speed, and the capacity for energy storage during hopping could increase as the kangaroo grows.
Keywords: Heart; laplace; marsupial; ontogeny; remodelling; stereology
Rights: © 2015. Published by The Company of Biologists Ltd
RMID: 0030027592
DOI: 10.1242/jeb.119453
Grant ID:
Appears in Collections:Earth and Environmental Sciences publications

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