Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/92699
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Type: Journal article
Title: Altering blood flow does not reveal differences between nitrogen and helium kinetics in brain or in skeletal miracle in sheep
Author: Doolette, D.
Upton, R.
Grant, C.
Citation: Journal of Applied Physiology, 2015; 118(5):586-594
Publisher: American Physiological Society
Issue Date: 2015
ISSN: 8750-7587
1522-1601
Statement of
Responsibility: 
David J. Doolette, Richard N. Upton, Cliff Grant
Abstract: In underwater diving, decompression schedules are based on compartmental models of nitrogen and helium tissue kinetics. However, these models are not based on direct measurements of nitrogen and helium kinetics. In isoflurane-anesthetized sheep, nitrogen and helium kinetics in the hind limb (n = 5) and brain (n = 5) were determined during helium-oxygen breathing and after return to nitrogen-oxygen breathing. Nitrogen and helium concentrations in arterial, femoral vein, and sagittal sinus blood samples were determined using headspace gas chromatography, and venous blood flows were monitored continuously using ultrasonic Doppler. The experiment was repeated at different states of hind limb blood flow and cerebral blood flow. Using arterial blood gas concentrations and blood flows as input, parameters and model selection criteria of various compartmental models of hind limb and brain were estimated by fitting to the observed venous gas concentrations. In both the hind limb and brain, nitrogen and helium kinetics were best fit by models with multiexponential kinetics. In the brain, there were no differences in nitrogen and helium kinetics. Hind limb models fit separately to the two gases indicated that nitrogen kinetics were slightly faster than helium, but models with the same kinetics for both gases fit the data well. In the hind limb and brain, the blood:tissue exchange of nitrogen is similar to that of helium. On the basis of these results, it is inappropriate to assign substantially different time constants for nitrogen and helium in all compartments in decompression algorithms.
Keywords: gases; pharmacokinetics; decompression sickness
Rights: © 2015 the American Physiological Society
RMID: 0030028901
DOI: 10.1152/japplphysiol.00944.2014
Grant ID: http://purl.org/au-research/grants/nhmrc/970067
Appears in Collections:Medicine publications

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