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Type: Journal article
Title: Costs and effects of screening and treating low risk women with a singleton pregnancy for asymptomatic bacteriuria, the ASB study
Author: Kazemier, B.
Schneeberger, C.
de Miranda, E.
van Wassenaer, A.
Bossuyt, P.
Vogelvang, T.
Reijnders, F.
Delemarre, F.
Verhoeven, C.
Oudijk, M.
van der Ven, J.
Kuiper, P.
Feiertag, N.
Ott, A.
de Groot, C.
Mol, B.
Geerlings, S.
Citation: BMC Pregnancy and Childbirth, 2012; 12(52):1-5
Publisher: BioMed Central
Issue Date: 2012
ISSN: 1471-2393
Statement of
Brenda M Kazemier, Caroline Schneeberger, Esteriek De Miranda, Aleid Van Wassenaer, Patrick M Bossuyt, Tatjana E Vogelvang, Frans JL Reijnders, Friso MC Delemarre, Corine JM Verhoeven, Martijn A Oudijk, Jeanine A Van Der Ven, Petra N Kuiper, Nicolette Feiertag, Alewijn Ott, Christianne JM De Groot, Ben Willem J Mol, and Suzanne E Geerlings
Abstract: Background: The prevalence of asymptomatic bacteriuria (ASB) in pregnancy is 2-10% and is associated with both maternal and neonatal adverse outcomes as pyelonephritis and preterm delivery. Antibiotic treatment is reported to decrease these adverse outcomes although the existing evidence is of poor quality. Methods/Design: We plan a combined screen and treat study in women with a singleton pregnancy. We will screen women between 16 and 22 weeks of gestation for ASB using the urine dipslide technique. The dipslide is considered positive when colony concentration ≥105 colony forming units (CFU)/mL of a single microorganism or two different colonies but one ≥105 CFU/mL is found, or when Group B Streptococcus bacteriuria is found in any colony concentration. Women with a positive dipslide will be randomly allocated to receive nitrofurantoin or placebo 100 mg twice a day for 5 consecutive days (double blind). Primary outcomes of this trial are maternal pyelonephritis and/or preterm delivery before 34 weeks. Secondary outcomes are neonatal and maternal morbidity, neonatal weight, time to delivery, preterm delivery rate before 32 and 37 weeks, days of admission in neonatal intensive care unit, maternal admission days and costs. Discussion: This trial will provide evidence for the benefit and cost-effectiveness of dipslide screening for ASB among low risk women at 16–22 weeks of pregnancy and subsequent nitrofurantoin treatment.
Keywords: Humans
Pregnancy Complications, Infectious
Anti-Infective Agents, Urinary
Mass Screening
Colony Count, Microbial
Research Design
Cost of Illness
Cost-Benefit Analysis
Rights: © 2012 Kazemier et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1186/1471-2393-12-52
Appears in Collections:Aurora harvest 7
Obstetrics and Gynaecology publications

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