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|Title:||The obesity-related FTO gene variant associates with the risk of recurrent miscarriage|
|Citation:||Acta Obstetricia et Gynecologica Scandinavica, 2015; 94(7):722-726|
|Prabha H. Andraweera, Gusta Af A. Dekker, Rohan W. Jayasekara, Vajira H.W. Dissanayake, & Claire T. Roberts|
|Abstract:||Objective. To investigate the association of the fat mass and obesity associated gene (FTO) rs9939609 single nucleotide polymorphism with recurrent miscar- riage. Design. Candidate gene association study. Setting. Human Genetics Unit, Colombo, Sri Lanka. Population. A total of 202 Sinhalese women with two or more ﬁrst-trimester miscarriages and no living children (cases) and 202 age- and ethnicity-matched women with no history of miscarriage and having two or more living children (controls). Methods. Peripheral blood was collected from the participants and DNA was extracted. Genotyping was performed at the Australian genome Research Facility using the Sequenom MassARRAY sys- tem. Genotype and allele frequencies of cases were compared with controls using chi-squared testing. Main outcome measures. The prevalence of the single nucleotide polymorphism in cases and controls. Results. The mean age of the women in the recurrent miscarriage group was 31.9 0.4 years and that of the control group was 32.3 0.3 years. Of the women in the recurrent miscar- riage group, 140 (69.3%) had experienced three or more ﬁrst-trimester miscar- riages. The prevalence of the AA genotype [p = 0.0002, odds ratio (95% CI) = 3.8 (1.8–8.0)] and A allele [p = 0.002, odds ratio (95% CI) = 1.6 (1.2–2.2)] of the FTO rs9939609 single nucleotide polymorphism were increased in women in the recurrent miscarriage group compared with the control group. Conclusion. The obesity-related FTO rs9939609 single nucleotide polymorphism associates with recurrent miscarriage. This ﬁnding warrants fur- ther investigation with controlling for important factors such as body mass index, diabetes and cardiovascular disease status. The single nucleotide poly- morphism may be useful in predicting the risk of recurrent miscarriage.|
|Keywords:||Recurrent miscarriage; FTO rs9939609; polymorphism|
|Rights:||© 2015 Nordic Federation of Societies of Obstetrics and Gynecology|
|Appears in Collections:||Medicine publications|
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