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Type: Journal article
Title: Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin
Author: Hsieh, Y.
Taleski, D.
Wilkinson, B.
Wijeyewickrema, L.
Adams, T.
Pike, R.
Payne, R.
Citation: Chemical Communications, 2012; 48(10):1547-1549
Publisher: Royal Society of Chemistry
Issue Date: 2012
ISSN: 1359-7345
Statement of
Yves S. Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrema, Ty E. Adams, Robert N. Pike and Richard J. Payne
Abstract: Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.
Rights: © the Authors
RMID: 0030010164
DOI: 10.1039/c1cc14773k
Grant ID:
Appears in Collections:Agriculture, Food and Wine publications

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