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|Title:||Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin|
|Citation:||Chemical Communications, 2012; 48(10):1547-1549|
|Publisher:||Royal Society of Chemistry|
|Yves S. Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrema, Ty E. Adams, Robert N. Pike and Richard J. Payne|
|Abstract:||Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.|
|Rights:||© the Authors|
|Appears in Collections:||Agriculture, Food and Wine publications|
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