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Type: Journal article
Title: Reviving old antibiotics
Author: Theuretzbacher, U.
Van Bambeke, F.
Cantón, R.
Giske, C.
Mouton, J.
Nation, R.
Paul, M.
Turnidge, J.
Kahlmeter, G.
Citation: Journal of Antimicrobial Chemotherapy, 2015; 70(8):2177-2181
Publisher: Oxford University Press
Issue Date: 2015
ISSN: 0305-7453
Statement of
Ursula Theuretzbacher, Franc, oise Van Bambeke, Rafael Canto, n, Christian G. Giske, Johan W. Mouton, Roger L. Nation, Mical Paul, John D. Turnidge, and Gunnar Kahlmeter
Abstract: In the face of increasing antimicrobial resistance and the paucity of new antimicrobial agents it has become clear that new antimicrobial strategies are urgently needed. One of these is to revisit old antibiotics to ensure that they are used correctly and to their full potential, as well as to determine whether one or several of them can help alleviate the pressure on more recent agents. Strategies are urgently needed to ‘re-develop’ these drugs using modern standards, integrating new knowledge into regulatory frameworks and communicating the knowledge from the research bench to the bedside. Without a systematic approach to re-developing these old drugs and rigorously testing them according to today's standards, there is a significant risk of doing harm to patients and further increasing multidrug resistance. This paper describes factors to be considered and outlines steps and actions needed to re-develop old antibiotics so that they can be used effectively for the treatment of infections.
Keywords: Humans
Bacterial Infections
Anti-Bacterial Agents
Drug Utilization
Drug-Related Side Effects and Adverse Reactions
Rights: © The Author 2015.
DOI: 10.1093/jac/dkv157
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