Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/93114
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Type: Journal article
Title: Consolidation and translation regulation
Author: Gal-Ben-Ari, S.
Kenney, J.
Ounalla-Saad, H.
Tahal, E.
David, O.
Levitan, D.
Gildish, I.
Panja, D.
Pai, B.
Wilbrand, K.
Simpson, I.
Proud, C.
Bramham, C.
Armstrong, D.
Rosenblum, K.
Citation: Learning and Memory, 2012; 19(9):410-422
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2012
ISSN: 1072-0502
1549-5485
Statement of
Responsibility: 
Shunit Gal-Ben-Ari, Justin W. Kenney, Hadile Ounalla-Saad, Elham Taha, Orit David, David Levitan, Iness Gildish, Debabrata Panja, Balagopal Pai, Karin Wibrand, T. Ian Simpson, Christopher G. Proud, Clive R. Bramham, J. Douglas Armstrong, and Kobi Rosenblum
Abstract: mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.
Keywords: Hippocampus
Cerebral Cortex
Neurons
Animals
Humans
Nervous System Diseases
MicroRNAs
Neurotransmitter Agents
Memory
Taste
Protein Biosynthesis
Gene Expression Regulation
Models, Molecular
Rights: © 2012 Cold Spring Harbor Laboratory Press
DOI: 10.1101/lm.026849.112
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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