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Type: Journal article
Title: Effects of intraduodenal infusions of L-phenylalanine and L-glutamine on antropyloroduodenal motility and plasma cholecystokinin in healthy men
Author: Steinert, R.
Landrock, M.
Horowitz, M.
Feinle-Bisset, C.
Citation: Journal of Neurogastroenterology and Motility, 2015; 21(3):404-413
Publisher: Journal of Neurogastroenterology and Motility
Issue Date: 2015
ISSN: 2093-0879
Statement of
Robert E Steinert, Maria F Landrock, Michael Horowitz, and Christine Feinle-Bisset
Abstract: BACKGROUND/AIMS Dietary proteins have potent eating-inhibitory and glucose-lowering effects, which may be mediated via effects of amino acids on gastrointestinal hormone and motor function, although little information is available. We have now evaluated the effects of L-phenylalanine (L-Phe) and L-glutamine (L-Gln) on antropyloroduodenal motility and plasma cholecystokinin (CCK) concentrations. METHODS Two double-blind, 3-way cross-over studies were performed, each including 10 healthy, normal-weight men. We determined the antropyloroduodenal motor and plasma CCK responses to 90-minute intraduodenal infusions of L-Phe (study A) or L-Gln (study B), each at 0.15 kcal/min (total 13.5 kcal), or 0.45 kcal/min (total 40.5 kcal), or saline (control), in randomized fashion. RESULTS Intraduodenal L-Phe at 0.45 kcal/min, but not at 0.15 kcal/min, suppressed antral (P < 0.01), and stimulated phasic (P < 0.01), but not tonic, pyloric, or duodenal pressures, while L-Phe at both 0.15 kcal/min and 0.45 kcal/min stimulated plasma CCK. In contrast, L-Gln had no effect on antral, duodenal or pyloric pressures, or plasma CCK. CONCLUSIONS Intraduodenal infusions of L-Phe and L-Gln, in doses of 0.15 kcal/min and 0.45 kcal/min for 90 minutes, have different effects on antropyloroduodenal motility and CCK in normal-weight men. The modulation of antral and pyloric pressures and CCK may contribute to the eating-inhibitory effects of oral L-Phe, possibly through the slowing of gastric emptying.
Keywords: Amino acids; Eating; Gastrointestinal hormones; Gastrointestinal motility; Humans
Rights: © The Korean Society of Neurogastroenterology and Motility. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit (
DOI: 10.5056/jnm14143
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