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dc.contributor.authorCamacho, A.en
dc.contributor.authorHuang, J.en
dc.contributor.authorDelint-Ramirez, I.en
dc.contributor.authorTan, C.en
dc.contributor.authorFuller, M.en
dc.contributor.authorLelliott, C.en
dc.contributor.authorVidal-Puig, A.en
dc.contributor.authorFranklin, R.en
dc.identifier.citationEuropean Journal of Neuroscience, 2013; 38(5):2672-2683en
dc.description.abstractPeroxisome proliferator-activated receptor gamma-coactivator-1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegenerative changes in the striatum. Here we performed lipidomic analysis on brain extracts from PGC1a mutant and wild-type mice. We found increased phosphatidylcholine and decreased ceramides in the brain of PGC1a-deficient mice. An analysis of lipid raft fractions revealed increased ceramide, glucocylceramides and GM1 ganglioside in the PGC1a mutants. In the cerebellum, we observed a decrease in proteins associated with myelination, but were unable to detect any morphological abnormalities in compact myelin formation in PGC1a mutants compared with wild-type mice. Although PGC1a is involved in lipid biosynthesis, we concluded that altered lipid composition in the PGC1a mutant did not directly affect central nervous system myelin morphology.en
dc.description.statementofresponsibilityAlberto Camacho, Jeffrey K. Huang, Ilse Delint-Ramirez, Chong Yew Tan, Maria Fuller, Christopher J. Lelliott, Antonio Vidal-Puig, and Robin J. M. Franklinen
dc.rights© 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltden
dc.subjectlipid rafts; lipidomics;mouse; myelin; oligodendrocyte; peroxisome proliferator-activated receptor gamma-coactivator-1 alphaen
dc.titlePeroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesisen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidFuller, M. [0000-0001-9092-8942]en
Appears in Collections:Medicine publications

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