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Type: Journal article
Title: Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis
Author: Camacho, A.
Huang, J.
Delint-Ramirez, I.
Tan, C.
Fuller, M.
Lelliott, C.
Vidal-Puig, A.
Franklin, R.
Citation: European Journal of Neuroscience, 2013; 38(5):2672-2683
Publisher: Wiley
Issue Date: 2013
ISSN: 0953-816X
Statement of
Alberto Camacho, Jeffrey K. Huang, Ilse Delint-Ramirez, Chong Yew Tan, Maria Fuller, Christopher J. Lelliott, Antonio Vidal-Puig, and Robin J. M. Franklin
Abstract: Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegenerative changes in the striatum. Here we performed lipidomic analysis on brain extracts from PGC1a mutant and wild-type mice. We found increased phosphatidylcholine and decreased ceramides in the brain of PGC1a-deficient mice. An analysis of lipid raft fractions revealed increased ceramide, glucocylceramides and GM1 ganglioside in the PGC1a mutants. In the cerebellum, we observed a decrease in proteins associated with myelination, but were unable to detect any morphological abnormalities in compact myelin formation in PGC1a mutants compared with wild-type mice. Although PGC1a is involved in lipid biosynthesis, we concluded that altered lipid composition in the PGC1a mutant did not directly affect central nervous system myelin morphology.
Keywords: lipid rafts; lipidomics;mouse; myelin; oligodendrocyte; peroxisome proliferator-activated receptor gamma-coactivator-1 alpha
Rights: © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
RMID: 0030032128
DOI: 10.1111/ejn.12281
Appears in Collections:Medicine publications

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