Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/93273
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dc.contributor.authorSchmid, B.en
dc.contributor.authorRezniczek, G.en
dc.contributor.authorRolf, N.en
dc.contributor.authorSaade, G.en
dc.contributor.authorGebauer, G.en
dc.contributor.authorMaul, H.en
dc.date.issued2013en
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology, 2013; 209(3):225.e1-225.e5en
dc.identifier.issn0002-9378en
dc.identifier.issn1097-6868en
dc.identifier.urihttp://hdl.handle.net/2440/93273-
dc.description.abstractOBJECTIVE: To describe the use of gauze covered with chitosan, a potent hemostatic agent derived from chitin, in the treatment of postpartum hemorrhage (PPH). STUDY DESIGN: Patients suffering from postpartum hemorrhage were treated by uterine packing with chitosan-covered gauze, either through the hysterotomy in case of cesarean delivery or transvaginally, for up to 24 hours. RESULTS: Chitosan-covered gauze was used in 19 cases of postpartum hemorrhage due to uterine atony, placenta accreta/increta, or anticoagulation, including 5 severe cases where a hysterectomy seemed inevitable otherwise. In all but one case, the bleeding stopped and further interventions were avoided. Over comparable periods of time (18 months) and births (3822 vs 4077) before and after the introduction of the chitosan gauze in our clinic, the rate of peripartum hysterectomies was reduced by 75% (8 vs 2; odds ratio, 4.27; P = .044). CONCLUSION: Chitosan-covered gauze is a viable option in the treatment of (severe) postpartum hemorrhage. It is easy to use and requires no special training. It can be used after both vaginal and cesarean deliveries, and there are no adverse side effects. Furthermore, it is very inexpensive compared with other treatment options, making it suitable for use also in low resource-countries, where the death toll due to postpartum hemorrhage is especially high.en
dc.description.statementofresponsibilityBernd C. Schmid, Günther A. Rezniczek, Norbert Rolf, George Saade, Gerhard Gebauer, Holger Maulen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2013 Mosby, Inc. All rights reserved.en
dc.subjectPostpartum Hemorrhageen
dc.titleUterine packing with chitosan-covered gauze for control of postpartum hemorrhageen
dc.typeJournal articleen
dc.identifier.doi10.1016/j.ajog.2013.05.055en
pubs.publication-statusPublisheden
Appears in Collections:Obstetrics and Gynaecology publications

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