Systematic screening identifies dual PI3K and mTOR Inhibition as a conserved therapeutic vulnerability in osteosarcoma

Gupte, A.; Baker, E.; Wan, S.; Stewart, E.; Loh, A.; Shelat, A.; Gould, C.; Chalk, A.; Taylor, S.; Lackovic, K.; Karlström, Å.; Mutsaers, A.; Desai, J.; Madhamshettiwar, P.; Zannettino, A.; Burns, C.; Huang, D.; Dyer, M.; Simpson, K.; Walkley, C.

Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/93460

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Type:	Journal article
Title:	Systematic screening identifies dual PI3K and mTOR Inhibition as a conserved therapeutic vulnerability in osteosarcoma
Author:	Gupte, A. Baker, E. Wan, S. Stewart, E. Loh, A. Shelat, A. Gould, C. Chalk, A. Taylor, S. Lackovic, K. Karlström, Å. Mutsaers, A. Desai, J. Madhamshettiwar, P. Zannettino, A. Burns, C. Huang, D. Dyer, M. Simpson, K. Walkley, C.
Citation:	Clinical Cancer Research, 2015; 21(14):3216-3229
Publisher:	American Association for Cancer Research
Issue Date:	2015
ISSN:	1557-3265 1557-3265
Statement of Responsibility:	Ankita Gupte, Emma K. Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A. Shelat, Cathryn M. Gould, Alistair M. Chalk, Scott Taylor, Kurt Lackovic, Åsa Karlstr, om, Anthony J. Mutsaers, Jayesh Desai, Piyush B. Madhamshettiwar, Andrew C.W. Zannettino, Chris Burns, David C.S. Huang, Michael A. Dyer, Kaylene J. Simpson, and Carl R.Walkley
Abstract:	Abstract not available
Keywords:	Animals Humans Mice Osteosarcoma Bone Neoplasms Disease Models, Animal RNA, Small Interfering Antineoplastic Agents Drug Screening Assays, Antitumor Xenograft Model Antitumor Assays Genetic Engineering Cell Proliferation TOR Serine-Threonine Kinases High-Throughput Nucleotide Sequencing Phosphoinositide-3 Kinase Inhibitors
Description:	Disclosure of Potential Conflicts of Interest J. Desai is a consultant/advisory board member for GlaxoSmithKline, Novartis, and Roche. No potential conflicts of interest were disclosed by the other authors.
Rights:	©2015 American Association for Cancer Research.
DOI:	10.1158/1078-0432.ccr-14-3026
Grant ID:	http://purl.org/au-research/grants/nhmrc/1016701
Published version:	http://dx.doi.org/10.1158/1078-0432.ccr-14-3026
Appears in Collections:	Aurora harvest 2 Medicine publications

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