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dc.contributor.authorMakrides, M.-
dc.contributor.authorNeumann, M.A.-
dc.contributor.authorSimmer, K.-
dc.contributor.authorGibson, R.A.-
dc.identifier.citationLipids, 1995; 30(10):941-948-
dc.description.abstractThe purpose of our study was to assess whether a supplement of fish oil (FO) and evening primrose oil (EPO) for formula-fed infants was capable of avoiding reductions in erythrocyte docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6) associated with standard formula feeding. Healthy, term infants, whose mothers chose to formula feed, were randomized to either a placebo or supplemented formula for their first 30 wk of life. A reference group of beast-fed infants also was enrolled. Erythrocyte fatty acids were measured by capillary gas chromatography on day 5 and in weeks 6, 16, and 30. Supplementation of formula with 0.36% of total fatty acids as DHA resulted in erythrocyte DHA being maintained at or above breast-fed levels for the entire 30-wk study period, and breast feeding (0.21% DHA) resulted in a modest fall in erythrocyte DHA relative to baseline (day 5) values. The level of erythrocyte DHA in placebo formula-fed infants was halved by week 16. AA levels decreased in all infants in the first six weeks, but the levels in breast- and placebo formula-fed infants increased with age and returned to approximate baseline (day 5) values by 16 and 30 wk of age, respectively. Erythrocyte AA in FO+EPO-supplemented infants remained low and below breast- and placebo formula-fed levels. Our data suggest that dietary supplementation with DHA at 0.36% total fatty acids results in erythrocyte DHA levels above those found in breast-fed infants. EPO supplementation was not effective at maintaining erythrocyte AA when given with FO.-
dc.description.statementofresponsibilityMaria Makrides, Mark A. Neumann, Karen Simmer and Robert A. Gibson-
dc.publisherSpringer Verlag-
dc.rightsCopyright © 1995 by AOCS Press-
dc.subjectMilk, Human-
dc.subjectOenothera biennis-
dc.subjectDietary Fats, Unsaturated-
dc.subjectFatty Acids, Omega-3-
dc.subjectDocosahexaenoic Acids-
dc.subjectFatty Acids-
dc.subjectFatty Acids, Unsaturated-
dc.subjectArachidonic Acid-
dc.subjectFatty Acids, Essential-
dc.subjectLinoleic Acids-
dc.subjectgamma-Linolenic Acid-
dc.subjectFatty Acids, Omega-6-
dc.subjectFish Oils-
dc.subjectPlant Oils-
dc.subjectInfant Food-
dc.subjectInfant, Newborn-
dc.titleErythrocyte fatty-acids of term infants fed either breast-milk, standard formula, or formula supplemented with long-chain polyunsaturates-
dc.typeJournal article-
dc.identifier.orcidMakrides, M. [0000-0003-3832-541X]-
dc.identifier.orcidGibson, R.A. [0000-0002-8750-525X]-
Appears in Collections:Aurora harvest 7
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