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https://hdl.handle.net/2440/93570
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Type: | Journal article |
Title: | Erythrocyte fatty-acids of term infants fed either breast-milk, standard formula, or formula supplemented with long-chain polyunsaturates |
Author: | Makrides, M. Neumann, M.A. Simmer, K. Gibson, R.A. |
Citation: | Lipids, 1995; 30(10):941-948 |
Publisher: | Springer Verlag |
Issue Date: | 1995 |
ISSN: | 1558-9307 1558-9307 |
Statement of Responsibility: | Maria Makrides, Mark A. Neumann, Karen Simmer and Robert A. Gibson |
Abstract: | The purpose of our study was to assess whether a supplement of fish oil (FO) and evening primrose oil (EPO) for formula-fed infants was capable of avoiding reductions in erythrocyte docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6) associated with standard formula feeding. Healthy, term infants, whose mothers chose to formula feed, were randomized to either a placebo or supplemented formula for their first 30 wk of life. A reference group of beast-fed infants also was enrolled. Erythrocyte fatty acids were measured by capillary gas chromatography on day 5 and in weeks 6, 16, and 30. Supplementation of formula with 0.36% of total fatty acids as DHA resulted in erythrocyte DHA being maintained at or above breast-fed levels for the entire 30-wk study period, and breast feeding (0.21% DHA) resulted in a modest fall in erythrocyte DHA relative to baseline (day 5) values. The level of erythrocyte DHA in placebo formula-fed infants was halved by week 16. AA levels decreased in all infants in the first six weeks, but the levels in breast- and placebo formula-fed infants increased with age and returned to approximate baseline (day 5) values by 16 and 30 wk of age, respectively. Erythrocyte AA in FO+EPO-supplemented infants remained low and below breast- and placebo formula-fed levels. Our data suggest that dietary supplementation with DHA at 0.36% total fatty acids results in erythrocyte DHA levels above those found in breast-fed infants. EPO supplementation was not effective at maintaining erythrocyte AA when given with FO. |
Keywords: | Erythrocytes Milk, Human Humans Oenothera biennis Dietary Fats, Unsaturated Fatty Acids, Omega-3 Docosahexaenoic Acids Fatty Acids Fatty Acids, Unsaturated Arachidonic Acid Fatty Acids, Essential Linoleic Acids gamma-Linolenic Acid Fatty Acids, Omega-6 Fish Oils Plant Oils Aging Infant Food Infant, Newborn |
Rights: | Copyright © 1995 by AOCS Press |
DOI: | 10.1007/BF02537486 |
Published version: | http://dx.doi.org/10.1007/bf02537486 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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