Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/93583
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Type: Journal article
Title: The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
Other Titles: The effect on human tumor necrosis factor alpha and interleukin 1beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil
Author: Caughey, G.
Mantzioris, E.
Gibson, R.
Cleland, L.
James, M.
Citation: American Journal of Clinical Nutrition, 1996; 63(1):116-122
Publisher: American Society for Clinical Nutrition
Issue Date: 1996
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Gillian E Caughey, Evangeline Mantzioris, Robert A Gibson, Leslie G Cleland, and Michael J James
Abstract: The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximately 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n--3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested alpha-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximately 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n--3 fatty acids inhibit TNF alpha and IL-1 beta synthesis.
Keywords: flaxseed oil; monocytes
Rights: © 1996 by The American Society for Clinical Nutrition, Inc
RMID: 0030016284
DOI: 10.1093/ajcn/63.1.116
Appears in Collections:Agriculture, Food and Wine publications

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