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https://hdl.handle.net/2440/93712
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dc.contributor.author | Hope, C. | - |
dc.contributor.author | Troelnikov, A. | - |
dc.contributor.author | Hanf, W. | - |
dc.contributor.author | Jesudason, S. | - |
dc.contributor.author | Coates, P. | - |
dc.contributor.author | Heeger, P. | - |
dc.contributor.author | Carroll, R. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Kidney International, 2015; 88(6):1374-1382 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.issn | 1523-1755 | - |
dc.identifier.uri | http://hdl.handle.net/2440/93712 | - |
dc.description | Advance online publication 12 August 2015 | - |
dc.description.abstract | Reducing immunosuppression has been proposed as a means of preventing cancer in kidney transplant recipients but this can precipitate graft rejection. Here we tested whether anti-tumor natural killer (NK) cell and allo-responsive T-cell function in kidney transplant recipients may predict cancer risk and define risk of rejection. NK cell function was measured by the release of lactate dehydrogenase and T-cell allo-response by interferon-γ quantification using a panel of reactive T-cell enzyme-linked immunospot (ELISPOT) in 56 kidney transplant recipients with current or past cancer and 26 kidney transplant recipients without cancer. NK function was significantly impaired and the allo-response was significantly lower in kidney transplant recipients with cancer. With prospective follow-up, kidney transplant recipients with poor NK cell function had a hazard ratio of 2.1 (95% confidence interval 0.97-5.00) for the combined end point of metastatic cancer, cancer-related death, or septic death. Kidney transplant recipients with low interferon-γ release were also more likely to reach this combined end point. Thus, posttransplant monitoring of allo-immunity and NK cell function is useful for assessing the risk of over immunosuppression for the development of malignancy and/or death from cancer or sepsis. | - |
dc.description.statementofresponsibility | Christopher M Hope, Alexander Troelnikov, William Hanf, Shilpanjali Jesudason, Patrick T Coates, Peter S Heeger, and Robert P Carroll | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2015 International Society of Nephrology | - |
dc.source.uri | http://dx.doi.org/10.1038/ki.2015.237 | - |
dc.subject | cancer; IFN-γ ELISPOT; immunosuppression; kidney transplantation; NK cells | - |
dc.title | Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ki.2015.237 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hope, C. [0000-0001-8206-1939] | - |
dc.identifier.orcid | Jesudason, S. [0000-0001-9695-0761] | - |
dc.identifier.orcid | Carroll, R. [0000-0002-6238-026X] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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