Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/93985
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGrieger, J.en
dc.contributor.authorMiller, M.en
dc.contributor.authorCobiac, L.en
dc.date.issued2014en
dc.identifier.citationFood & Nutrition Research, 2014; 58(1):20369-1-20369-11en
dc.identifier.issn1654-6628en
dc.identifier.issn1654-661Xen
dc.identifier.urihttp://hdl.handle.net/2440/93985-
dc.description.abstractBACKGROUND: Aging is a condition of chronic inflammation. In healthy Australians ≥64 years, the primary aim was to determine whether four servings/week of mixed fish (FISH) improves serum cytokines (i.e. C-reactive protein (CRP), IL-1, IL-6, TNF-α) compared to a diet low in fish (<1 serving/week, CONTROL); the secondary aims were to assess the effect of the diet on blood pressure and serum lipids (TC, HDL-C, TG, calculated LDL-C). METHODS: An 8-week randomized, parallel study, stratified by CRP (<3 mg/L vs. ≥3 mg/L) on entry to the study. Compliance was measured using 3-day weighed food records in weeks 1 and 7 of the study. A 12-h fasting blood sample was taken at baseline and 8-weeks for erythrocyte fatty acids as confirmation of compliance, and measurement of serum cytokines and lipids. Blood pressure was measured at both time points. RESULTS: EIGHTY PARTICIPANTS COMPLETED THE STUDY (MEAN (SD) AGE: 69.6 (5.8) years). During week 1 of the study, mean ± SEM daily dietary intake of very long chain omega-3 polyunsaturated fatty acids (VLCN n-3 PUFA) in FISH vs. CONTROL was 1,676±129 mg vs. 27±5 mg (p<0.001). Mean (SD) gram intake of study fish and meat was 121 (45) g and 123 (78) g, for those allocated to FISH and CONTROL, respectively. Mean ± SEM percentage VLCN n-3 PUFA in erythrocytes at 8-weeks was higher in those allocated to FISH vs. CONTROL (10.2±0.2% vs. 8.2±0.3%, p<0.001). There was no between-group difference in CRP (n=80), IL-1β (n=33) or IL-6 (n=21) concentrations, blood pressure, or lipids, at 8-weeks. CONCLUSIONS: Eight weeks consumption of four servings/week fish did not affect serum cytokine concentrations, blood pressure or lipids compared to a diet low in fish. In healthy older adults with low inflammatory burden, our results do not support that short-term consumption of mixed fish has a beneficial effect on selected cardiovascular biomarkers.en
dc.description.statementofresponsibilityJessica A. Grieger, Michelle D. Miller, and Lynne Cobiaen
dc.language.isoenen
dc.publisherCo-action Publishingen
dc.rights© 2014 Jessica A. Grieger et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectolder adults; fish; C-reactive protein; omega-3 long chain fatty acids; blood pressure; lipidsen
dc.titleInvestigation of the effects of a high fish diet on inflammatory cytokines, blood pressure, and lipids in healthy older Australiansen
dc.typeJournal articleen
dc.identifier.rmid0030028581en
dc.identifier.doi10.3402/fnr.v58.20369en
dc.identifier.pubid114318-
pubs.library.collectionPaediatrics publicationsen
pubs.library.teamDS08en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGrieger, J. [0000-0003-1515-948X]en
Appears in Collections:Paediatrics publications

Files in This Item:
File Description SizeFormat 
hdl_ 93985.pdfPublished version421.12 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.