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|Title:||Silica microcapsules from diatoms as new carrier for delivery of therapeutics|
|Citation:||Nanomedicine, 2011; 6(7):1159-1173|
|Moom Sinn Aw, Spomenka Simovic, Jonas Addai-Mensah & Dusan Losic|
|Abstract:||Aim: This study explores the use of natural silica-based porous material from diatoms, known as diatomaceous earth, as a drug carrier of therapeutics for implant- and oral-delivery applications. Materials & Methods: To prove this concept, two drugs models were used and investigated: a hydrophobic (indomethacin) and hydrophilic (gentamicin). Results & Discussion: Results show the effectiveness of diatom microcapsules for drug-delivery application, showing 14–22 wt% drug loading capacity and sustained drug release over 2 weeks. Two steps in the drug release from diatom structures were observed: the first, rapid release (over 6 h is attributed to the surface deposited drug) and the second, slow and sustained release over 2 weeks with zero order kinetics. Conclusion: These results confirm that natural material based on diatom silica can be successfully applied as a drug carrier for both oral and implant drug-delivery applications, offering considerable potential to replace existing synthetic nanomaterials.|
|Keywords:||Diatoms; Silicon Dioxide; Indomethacin; Gentamicins; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Drug Carriers; Anti-Bacterial Agents; Porosity|
|Rights:||Copyright status unknown|
|Appears in Collections:||Chemical Engineering publications|
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