Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9405
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dc.contributor.authorRayner, C.en
dc.contributor.authorSamsom, M.en
dc.contributor.authorJones, K.en
dc.contributor.authorHorowitz, M.en
dc.date.issued2001en
dc.identifier.citationDiabetes Care, 2001; 24(2):371-381en
dc.identifier.issn0149-5992en
dc.identifier.issn1935-5548en
dc.identifier.urihttp://hdl.handle.net/2440/9405-
dc.descriptionCopyright © 2001 American Diabetes Associationen
dc.description.abstractAcute changes in the blood glucose concentration have a major reversible effect on esophageal, gastric, intestinal, gallbladder, and anorectal motility in both healthy subjects and diabetic patients. For example, gastric emptying is slower during hyperglycemia than euglycemia and accelerated during hypoglycemia. Acute hyperglycemia also affects perceptions arising from the gastrointestinal tract and may, accordingly, be important in the etiology of gastrointestinal symptoms in diabetes. Elevations in blood glucose that are within the normal postprandial range also affect gastrointestinal motor and sensory function. Upper gastrointestinal motor function is a critical determinant of postprandial blood glucose concentrations by influencing the absorption of ingested nutrients. Interventions that reduce postprandial hyperglycemia, by modulating the rate of gastric emptying, have the potential to become mainstream therapies in the treatment of diabetes.en
dc.description.statementofresponsibilityChristopher K. Rayner, Melvin Samsom, Karen L. Jones and Michael Horowitzen
dc.language.isoenen
dc.publisherAmer Diabetes Assocen
dc.subjectDigestive System; Intestine, Small; Esophagus; Stomach; Humans; Diabetes Mellitus; Hyperglycemia; Hypoglycemia; Glucose; Blood Glucose; Sensation; Gastrointestinal Motility; Gastric Emptyingen
dc.titleRelationships of upper gastrointestinal motor and sensory function with glycemic controlen
dc.typeJournal articleen
dc.identifier.rmid0020012034en
dc.identifier.doi10.2337/diacare.24.2.371en
dc.identifier.pubid61109-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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