Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9409
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dc.contributor.authorHorowitz, M.en
dc.contributor.authorO'Donovan, D.en
dc.contributor.authorJones, K.en
dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorRayner, C.en
dc.contributor.authorSamsom, M.en
dc.date.issued2002en
dc.identifier.citationDiabetic Medicine, 2002; 19(3):177-194en
dc.identifier.issn0742-3071en
dc.identifier.issn1464-5491en
dc.identifier.urihttp://hdl.handle.net/2440/9409-
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstractThe outcome of recent studies has led to redefinition of concepts relating to the prevalence, pathogenesis and clinical significance of disordered gastric emptying in patients with diabetes mellitus. The use of scintigraphic techniques has established that gastric emptying is abnormally slow in approx. 30-50% of outpatients with long-standing Type 1 or Type 2 diabetes, although the magnitude of this delay is modest in many cases. Upper gastrointestinal symptoms occur frequently and affect quality of life adversely in patients with diabetes, although the relationship between symptoms and the rate of gastric emptying is weak. Acute changes in blood glucose concentration affect both gastric motor function and upper gastrointestinal symptoms. Gastric emptying is slower during hyperglycaemia when compared with euglycaemia and accelerated during hypoglycaemia. The blood glucose concentration may influence the response to prokinetic drugs. Conversely, the rate of gastric emptying is a major determinant of post-prandial glycaemic excursions in healthy subjects, as well as in Type 1 and Type 2 patients. A number of therapies currently in development are designed to improve post-prandial glycaemic control by modulating the rate of delivery of nutrients to the small intestine.en
dc.description.statementofresponsibilityM. Horowitz, D. O’Donovan, K. L. Jones, C. Feinle, C. K. Rayner and M. Samsomen
dc.language.isoenen
dc.publisherBlackwell Science Ltden
dc.subjectstomach; gastric emptying; autonomic neuropathy; symptoms; glycaemic control; diagnosis; therapyen
dc.titleGastric emptying in diabetes: clinical significance and treatmenten
dc.typeJournal articleen
dc.identifier.rmid0020022159en
dc.identifier.doi10.1046/j.1464-5491.2002.00658.xen
dc.identifier.pubid59467-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
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