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https://hdl.handle.net/2440/9413
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dc.contributor.author | Brinkworth, G. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Parker, B. | - |
dc.contributor.author | Foster, P. | - |
dc.contributor.author | Clifton, P. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Diabetologia, 2004; 47(10):1677-1686 | - |
dc.identifier.issn | 0012-186X | - |
dc.identifier.issn | 1432-0428 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9413 | - |
dc.description.abstract | <h4>Aims/hypothesis</h4>This study compared the long-term weight loss and health outcomes at 1-year follow-up, after a 12-week intensive intervention consisting of two low-fat, weight-loss diets, which differed in protein content.<h4>Methods</h4>We randomly assigned 66 obese patients (BMI: 27-40 kg/m2) with type 2 diabetes to either a low-protein (15% protein, 55% carbohydrate) or high-protein diet (30% protein, 40% carbohydrate) for 8 weeks of energy restriction (approximately 6.7 MJ/day) and 4 weeks of energy balance. Subjects were asked to maintain the same dietary pattern for a further 12 months of follow-up.<h4>Results</h4>The study was completed by 38 of the subjects, with equal dropouts in each group. At Week 64, weight reductions against baseline were -2.2+/-1.1 kg (low protein) and -3.7+/-1.0 kg (high protein), p<0.01, with no diet effect. Fat mass was not different from baseline in either group. At Week 12, both diets reduced systolic and diastolic blood pressure by 6 and 3 mm Hg respectively, but blood pressure increased more with weight regain during follow-up in the low-protein group (p< or =0.04). At Week 64, both diets significantly increased HDL cholesterol and lowered C-reactive protein concentrations. There was no difference in the urinary urea : creatinine ratio at baseline between the two groups, but this ratio increased at Week 12 (in the high-protein group only, p<0.001, diet effect), remaining stable during follow-up in both diets.<h4>Conclusions/interpretation</h4>A high-protein weight-reduction diet may in the long term have a more favourable cardiovascular risk profile than a low-protein diet with similar weight reduction in people with type 2 diabetes. | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.source.uri | http://dx.doi.org/10.1007/s00125-004-1511-7 | - |
dc.subject | Adipose Tissue | - |
dc.subject | Humans | - |
dc.subject | Obesity | - |
dc.subject | Diabetes Complications | - |
dc.subject | Body Weight | - |
dc.subject | Lipids | - |
dc.subject | Dietary Proteins | - |
dc.subject | Diet, Fat-Restricted | - |
dc.subject | Diet, Protein-Restricted | - |
dc.subject | Diet, Reducing | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Blood Pressure | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Diet, Diabetic | - |
dc.title | Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with Type 2 diabetes: one-year follow-up of a randomised trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s00125-004-1511-7 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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