Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/94148
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dc.contributor.authorTrahair, L.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorStevens, J.en
dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorStandfield, S.en
dc.contributor.authorPiscitelli, D.en
dc.contributor.authorRayner, C.en
dc.contributor.authorDeane, A.en
dc.contributor.authorJones, K.en
dc.date.issued2015en
dc.identifier.citationDiabetologia, 2015; 58(8):1769-1778en
dc.identifier.issn0012-186Xen
dc.identifier.issn1432-0428en
dc.identifier.urihttp://hdl.handle.net/2440/94148-
dc.description.abstractAIMS/HYPOTHESIS: A postprandial fall in BP occurs frequently in older individuals and in patients with type 2 diabetes. The magnitude of this decrease in BP is related to the rate of gastric emptying (GE). Intravenous administration of glucagon-like peptide-1 (GLP-1) attenuates the hypotensive response to intraduodenal glucose in healthy older individuals. We sought to determine the effects of exogenous GLP-1 on BP, GE, superior mesenteric artery (SMA) flow and glycaemic response to oral ingestion of glucose in healthy older individuals and patients with type 2 diabetes. METHODS: Fourteen older volunteers (six men, eight women; age 72.1 ± 1.1 years) and ten patients with type 2 diabetes (six men, four women; age 68.7 ± 3.4 years; HbA1c 6.6 ± 0.2% [48.5 ± 2.0 mmol/mol]; nine with blood glucose managed with metformin, two with a sulfonylurea and one with a dipeptidyl-peptidase 4 inhibitor) received an i.v. infusion of GLP-1 (0.9 pmol kg(-1) min(-1)) or saline (154 mmol/l NaCl) for 150 min (t = -30 min to t = 120 min) in randomised order. At t = 0 min, volunteers consumed a radiolabelled 75 g glucose drink. BP was assessed with an automated device, GE by scintigraphy and SMA flow by ultrasonography. Blood glucose and serum insulin were measured. RESULTS: GLP-1 attenuated the fall in diastolic BP after the glucose drink in older individuals (p < 0.05) and attenuated the fall in systolic and diastolic BP in patients with type 2 diabetes (p < 0.05). GE was faster in patients with type 2 diabetes than in healthy individuals (p < 0.05). In both groups, individuals had slower GE (p < 0.001), decreased SMA flow (p < 0.05) and a lower degree of glycaemia (p < 0.001) when receiving GLP-1. CONCLUSIONS/INTERPRETATION: Intravenous GLP-1 attenuates the hypotensive response to orally administered glucose and decreases SMA flow, probably by slowing GE. GLP-1 and 'short-acting' GLP-1 agonists may be useful in the management of postprandial hypotension.en
dc.description.statementofresponsibilityLaurence G. Trahair, Michael Horowitz, Julie E. Stevens, Christine Feinle-Bisset, Scott Standfield, Diana Piscitelli, Christopher K. Rayner, Adam M. Deane, Karen L. Jonesen
dc.language.isoenen
dc.publisherSpringeren
dc.rights© Springer-Verlag Berlin Heidelberg 2015en
dc.subjectBlood pressure; Gastric emptying; Glucagon-like peptide-1; Glucoseen
dc.titleEffects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetesen
dc.typeJournal articleen
dc.identifier.rmid0030030641en
dc.identifier.doi10.1007/s00125-015-3638-0en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627189en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627011en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627002en
dc.identifier.pubid188357-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS08en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidDeane, A. [0000-0002-7620-5577]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
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