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Type: Journal article
Title: Long-term effects of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension
Author: Gschossmann, J.
Liebregts, T.
Adam, B.
Buenger, L.
Ruwe, M.
Gerken, G.
Holtmann, G.
Citation: Digestive Diseases and Sciences, 2004; 49(1):96-101
Publisher: Kluwer Academic/Plenum Publ
Issue Date: 2004
ISSN: 0163-2116
Statement of
J. M. Gschossmann, T. Liebregts, B. Adam, L. Buenger, M. Ruwe, G. Gerken and G. Holtmann
Abstract: Acute gastrointestinal infections with transient mucosal inflammation frequently precede the onset of functional GI disorders with altered visceral sensory function. We hypothesized that an acute inflammation of the mucosa is linked to long-lasting alterations of afferent visceral pathways. Utilizing abdominal wall electromyography, we tested the visceromotor response to tonic rectal distension (60 mm Hg/3 min) in fasted, conscious, male Lewis rats (n = 40) with a barostat device before and 2, 4, 15, and 17 weeks after rectal instillation of saline or trinitrobenzenesulfonic acid plus ethanol. Tissue samples from paired controls were obtained to assess histologic tissue alterations. Inflammatory changes were present up to 2 weeks after acid/ethanol instillation but not after saline instillation. Compared to baseline measurements, the visceromotor response to colorectal distension increased significantly and reached a maximum 17 weeks (P < 0.001)="" after="" induction="" of="" colitis,="" while="" it="" decreased="" in="" control="" experiments="">P < 0.05).="" in="" conclusion,="" these="" data="" suggest="" that="" an="" acute="" inflammation="" has="" long-term="" effects="" on="" somatosensory="">
Keywords: colorectal distension
visceral hyperalgesia
Rights: © 2004 Plenum Publishing Corporation
DOI: 10.1023/B:DDAS.0000011609.68882.3a
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