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|Title:||Survival after cystectomy for invasive bladder cancer|
|Author:||de Vries, R.|
van Tinteren, H.
|Citation:||European Journal of Surgical Oncology, 2010; 36(3):292-297|
|R.R. de Vries, J.A. Nieuwenhuijzen, A. Vincent, H. van Tinteren, S. Horenblas|
|Abstract:||<h4>Aim</h4>To determine the difference in survival after cystectomy between patients presenting with primary muscle infiltrating bladder cancer and patients with progression to muscle infiltration after treatment for initial non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>We retrospectively analyzed the files of 188 patients who underwent cystectomy for transitional cell carcinoma between 1987 and 2005. Two groups were defined: patients presenting with muscle-invasive tumours and those progressing to muscle invasion after initial treatment. This second group was further divided into low-intermediate and high risk according to the EAU grouping for NMIBC.<h4>Results</h4>The 5-year disease specific survival (95% confidence intervals) for all patients was 50%(42-59%); 49%(40-60%) in the primary muscle infiltrating group and 52%(37-74%) in the progressive group (p = ns). The 5-year disease specific survival in the progressive group according to EAU risk groups was 75%(58-97%) for the initially diagnosed low-intermediate risk tumours and 35%(17-71%) for the initially diagnosed high-risk tumours (p = 0.015). The percentage of patients with non-locally confined tumours (pT3/4-N0//any pT-N+) was 31%//45% and 24%//46% in the primary muscle infiltrating and progressive group, respectively.<h4>Conclusions</h4>Despite close observation of patients treated for non-muscle-invasive bladder cancer, the survival of patients who progress to muscle invasion is not better than survival of patients presenting with primary muscle infiltrating cancer. Patients with high-risk non-invasive tumours (EAU risk-categories) who progress to muscle-invasive disease have a worse prognosis compared to patients with low or intermediate risk tumours.|
|Keywords:||Bladder neoplasms; Cystectomy; Transitional cell carcinoma; Survival; High-risk non-muscle-invasive bladder cancer|
|Rights:||Copyright © 2009 Elsevier Ltd.|
|Appears in Collections:||Medicine publications|
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