Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/94534
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Distinct localisation of lipids in the ovarian follicular environment
Author: Pantasri, T.
Wu, L.
Hull, M.
Sullivan, T.
Barry, M.
Norman, R.
Robker, R.
Citation: Reproduction, Fertility and Development, 2015; 27(4):593-601
Publisher: CSIRO Publishing
Issue Date: 2015
ISSN: 1031-3613
1448-5990
Statement of
Responsibility: 
Tawiwan Pantasri, Linda L. Wu, M. Louise Hull, Thomas R. Sullivan, Michael Barry, Robert J. Norman and Rebecca L. Robker
Abstract: Obesity is associated with decreased pregnancy rates due, in part, to compromised oocyte quality. The aim of the present cross-sectional study of 84 women undergoing oocyte aspiration was to: (1) compare insulin, lipids and glucose in follicular fluid with serum; (2) determine whether increased body mass index (BMI) and waist circumference, hyperinsulinaemia, dyslipidaemia or metabolic syndrome altered follicular fluid metabolites; and (3) determine relative lipid content in oocytes to reveal any influence of these parameters on oocyte quality and IVF outcomes. Insulin, glucose, triglyceride and free fatty acids were lower in follicular fluid than blood and not strictly correlated between compartments. Insulin, glucose and triglyceride positively correlated with increasing BMI and waist circumference in blood and follicular fluid. Insulin increased in follicular fluid in association with metabolic syndrome. Free fatty acid composition analysis showed saturated fatty acids, particularly palmitic and stearic acid, to be more prevalent in follicular fluid than blood. There were no associations between follicular fluid metabolites or oocyte lipid content and clinical outcomes; however, oocyte immaturity correlated with follicular fluid glucose and fatty acid levels, as well as metabolic syndrome. The present study confirms that the human ovarian follicular environment surrounding the oocyte exhibits a unique metabolite profile compared with blood, with distinct localisation of lipids within follicular fluid and oocytes.
Keywords: Fatty acid; glucose; insulin; oocyte
Rights: Journal compilation © CSIRO 2015
RMID: 0030026545
DOI: 10.1071/RD14321
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.