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https://hdl.handle.net/2440/9463
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Type: | Journal article |
Title: | The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling |
Author: | Vajjhala, P. Macmillan, E. Gonda, T. Little, M. |
Citation: | FEBS Letters, 2003; 554(1-2):143-148 |
Publisher: | Elsevier Science BV |
Issue Date: | 2003 |
ISSN: | 0014-5793 1873-3468 |
Abstract: | The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation. |
Keywords: | Cell Line Animals Humans Mice Protein Sorting Signals Karyopherins WT1 Proteins Receptors, Cytoplasmic and Nuclear DNA, Complementary Transfection Transcription, Genetic Gene Expression Regulation Protein Processing, Post-Translational RNA Processing, Post-Transcriptional Amino Acid Sequence Active Transport, Cell Nucleus |
DOI: | 10.1016/S0014-5793(03)01144-X |
Published version: | http://dx.doi.org/10.1016/s0014-5793(03)01144-x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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