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|Title:||The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling|
|Citation:||FEBS Letters, 2003; 554(1-2):143-148|
|Publisher:||Elsevier Science BV|
|Abstract:||The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation.|
|Keywords:||Cell Line; Animals; Humans; Mice; Protein Sorting Signals; Karyopherins; WT1 Proteins; Receptors, Cytoplasmic and Nuclear; DNA, Complementary; Transfection; Transcription, Genetic; Gene Expression Regulation; Protein Processing, Post-Translational; RNA Processing, Post-Transcriptional; Amino Acid Sequence; Active Transport, Cell Nucleus|
|Appears in Collections:||Medicine publications|
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