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Type: Journal article
Title: The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling
Author: Vajjhala, P.
Macmillan, E.
Gonda, T.
Little, M.
Citation: FEBS Letters, 2003; 554(1-2):143-148
Publisher: Elsevier Science BV
Issue Date: 2003
ISSN: 0014-5793
Abstract: The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation.
Keywords: Cell Line; Animals; Humans; Mice; Protein Sorting Signals; Karyopherins; WT1 Proteins; Receptors, Cytoplasmic and Nuclear; DNA, Complementary; Transfection; Transcription, Genetic; Gene Expression Regulation; Protein Processing, Post-Translational; RNA Processing, Post-Transcriptional; Amino Acid Sequence; Active Transport, Cell Nucleus
RMID: 0020031358
DOI: 10.1016/S0014-5793(03)01144-X
Appears in Collections:Medicine publications

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