Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI
Author: Tsai, V.
Macia, L.
Feinle-Bisset, C.
Manandhar, R.
Astrup, A.
Raben, A.
Lorenzen, J.
Schmidt, P.
Wiklund, F.
Pedersen, N.
Campbell, L.
Kriketos, A.
Xu, A.
Zhou, P.
Jia, W.
Curmi, P.
Angstmann, C.
Lee-Ng, K.
Zhang, H.
Marquis, C.
et al.
Citation: PLoS One, 2015; 10(7):e0133362-1-e0133362-15
Publisher: Public Library of Science
Issue Date: 2015
ISSN: 1932-6203
Editor: Young, M.
Statement of
Vicky Wang-Wei Tsai ... Christine Feinle-Bisset ... et al.
Abstract: The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis. To further characterize the role of MIC-1/GDF15 in physiological regulation of energy homeostasis in man, we have examined diurnal and food associated variation in serum levels and whether variation in circulating levels relate to BMI in human monozygotic twin pairs. We found that the within twin pair differences in serum MIC-1/GDF15 levels were significantly correlated with within twin pair differences in BMI, suggesting a role for MIC-1/GDF15 in the regulation of energy balance in man. MIC-1/GDF15 serum levels altered slightly in response to a meal, but comparison with variation its serum levels over a 24 hour period suggested that these changes are likely to be due to bimodal diurnal variation which can alter serum MIC-1/GDF15 levels by about plus or minus 10% from the mesor. The lack of a rapid and substantial postprandial increase in MIC-1/GDF15 serum levels suggests that MIC1/GDF15 is unlikely to act as a satiety factor. Taken together, our findings suggest that MIC-1/GDF15 may be a physiological regulator of energy homeostasis in man, most probably due to actions on long-term regulation of energy homeostasis.
Keywords: Humans
Body Mass Index
Energy Metabolism
Circadian Rhythm
Postprandial Period
Aged, 80 and over
Middle Aged
Glucagon-Like Peptide 1
Growth Differentiation Factor 15
Young Adult
Rights: © 2015 Tsai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0133362
Appears in Collections:Aurora harvest 3
Medicine publications

Files in This Item:
File Description SizeFormat 
hdl_94718.pdfPublished version1.22 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.