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Type: Journal article
Title: TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice
Author: Kentish, S.
Frisby, C.
Kritas, S.
Li, H.
Hatzinikolas, G.
O'Donnell, T.
Wittert, G.
Page, A.
Citation: PLoS One, 2015; 10(8):e0135892-1-e0135892-15
Publisher: Public Library of Science
Issue Date: 2015
ISSN: 1932-6203
Statement of
Stephen J. Kentish, Claudine L. Frisby, Stamatiki Kritas, Hui Li, George Hatzinikolas, Tracey A. O, Donnell, Gary A. Wittert, Amanda J. Page
Abstract: Within the gastrointestinal tract vagal afferents play a role in control of food intake and satiety signalling. Activation of mechanosensitive gastric vagal afferents induces satiety. However, gastric vagal afferent responses to mechanical stretch are reduced in high fat diet mice. Transient receptor potential vanilloid 1 channels (TRPV1) are expressed in vagal afferents and knockout of TRPV1 reduces gastro-oesophageal vagal afferent responses to stretch. We aimed to determine the role of TRPV1 on gastric vagal afferent mechanosensitivity and food intake in lean and HFD-induced obese mice.
Keywords: Esophagus; Stomach; Vagus Nerve; Adipose Tissue; Animals; Mice, Inbred C57BL; Mice; Mice, Obese; Obesity; Body Weight; Signal Transduction; Mechanotransduction, Cellular; Eating; Male; TRPV Cation Channels; Gene Knockout Techniques; Diet, High-Fat
Rights: © 2015 Kentish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030033180
DOI: 10.1371/journal.pone.0135892
Appears in Collections:Medicine publications

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