Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/94856
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Type: Journal article
Title: Impact of intraoperative hydrodebrider treatment on postoperative sinonasal inflammation
Author: Banglawala, S.
Mulligan, J.
Psaltis, A.
Wang, E.
Nguyen, S.
Mulligan, R.
Crosby, B.
Schlosser, R.
Citation: American Journal of Rhinology and Allergy, 2014; 28(5):438-442
Publisher: OceanSide
Issue Date: 2014
ISSN: 1945-8924
1945-8932
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Responsibility: 
Banglawala, Sarfaraz M.; Mulligan, Jennifer K.; Psaltis, Alkis J.; Wang, Eric W.; Nguyen, Shaun A.; Mulligan, Ryan M.; Crosby, Brittany L; Schlosser, Rodney J.
Abstract: Background: The impact of intraoperative hydrodebrider sinus irrigation (HSI) during endoscopic sinus surgery (ESS) on postoperative inflammation, endoscopy, and patient-reported outcomes has not been studied. Methods: A clinical trial of 12 patients with symmetric chronic rhinosinusitis were prospectively randomized to HSI on one side after undergoing bilateral ESS. The contralateral side was not treated with any irrigation and served as an internal control. Preoperative computed tomography, endoscopic, 22-item Sino-Nasal Outcome Test (SNOT-22), and symptom visual analog scale (VAS) scores for each side were obtained. At 1 and 3 months postsurgery, endoscopy, SNOT-22, and sinus VAS were recorded. Sinonasal mucus levels of interleukin (IL)-6, IL-10, IL-17a, and tumor necrosis factor (TNF) alpha were measured at the time of surgery, 1 and 3 months, postoperatively, from each side. Results: VAS scores improved on both sides (p < 0.05) and SNOT-22 improved at all postoperative time points (p < 0.05). Endoscopic scores of HSI-treated sides did not improve compared with baseline. HSI had no additional significant impact on postoperative VAS at any time point. HSI significantly decreased IL-17a levels when compared with the control side at 1 month (p = 0.034) and 3 months (p = 0.031). No significant change was seen in TNF-alpha, IL-6, or IL-10 on either side at any time point. Conclusion: Intraoperative HSI at the time of ESS failed to establish any improvement in postoperative endoscopy or most local cytokine levels after ESS.
Keywords: CRS; ESS; endoscopy; hydrodebrider; sinonasal inflammation
Rights: Copyright status unknown
DOI: 10.2500/ajra.2014.28.4073
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