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Type: Journal article
Title: The estrogen hypothesis of obesity
Author: Grantham, J.
Henneberg, M.
Citation: PLoS One, 2014; 9(6):e99776-1-e99776-7
Publisher: Public Library of Science
Issue Date: 2014
ISSN: 1932-6203
Statement of
James P. Grantham, Maciej Henneberg
Abstract: The explanation of obesity as a simple result of positive energy balance fails to account for the scope of variable responses to diets and lifestyles. It is postulated that individual physiological and anatomical variation may be responsible for developing obesity. Girls in poor families develop greater adiposity than their male siblings, a trend not present in richer environments. This indicates strong influence of estrogen on fat accumulation irrespective of poor socioeconomic conditions. Obesity rates in males and females of developed nations are similar, while in poorer nations obesity is much more prevalent in females. Female to male ratio of obesity correlates inversely with gross domestic product. Therefore, the parity of male and female obesity in developed countries may result from male exposure to environmental estrogen-like substances associated with affluence. These hormonally driven mechanisms may be equally active within both sexes in more developed areas, thereby increasing overall obesity.
Keywords: Humans; Obesity; Guanosine Diphosphate; Estrogens; Skinfold Thickness; Siblings; Models, Biological; Developed Countries; Developing Countries; Rural Population; Urban Population; Female; Male
Rights: © 2014 Grantham, Henneberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030011433
DOI: 10.1371/journal.pone.0099776
Appears in Collections:Medicine publications

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