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https://hdl.handle.net/2440/9505
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Type: | Journal article |
Title: | Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses |
Author: | Croker, B. Handman, E. Hayball, J. Baldwin, T. Voigt, V. Cluse, L. Yang, F. Williams, D. Roberts, A. |
Citation: | Immunology and Cell Biology, 2002; 80(3):231-240 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2002 |
ISSN: | 0818-9641 1440-1711 |
Statement of Responsibility: | Ben A Croker, Emanuela Handman, John D Hayball, Tracey M Baldwin, Valentina Voigt, Leonie A Cluse, Feng-Chun Yang, David A Williams and Andrew W Roberts |
Abstract: | The haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (TH1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 deficiency results in an abnormal distribution of T lymphocytes in vivo and defects in T-lymphocyte migration and filamentous actin generation in response to chemoattractants in vitro. To investigate the requirement for Rac2 in IFN-gamma production and TH1 responses in vivo, Rac2-deficient mice were challenged with Leishmania major and immunized with ovalbumin-expressing cytomegalovirus. Despite a minor skewing towards a TH2 phenotype, Rac2-deficient mice displayed no increased susceptibility to L. major infection. Cytotoxic T-lymphocyte responses to cytomegalovirus and ovalbumin were also normal. Although Rac2 is required for normal T-lymphocyte migration, its role in the generation of TH1 responses to infection in vivo is largely redundant. |
Keywords: | chemotaxis Rac2 T lymphocytes TH1/TH2 |
Rights: | © 2002 Australasian Society for Immunology |
DOI: | 10.1046/j.1440-1711.2002.01077.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1711.2002.01077.x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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