Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/95061
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Hospitalization for drug-induced hepatotoxicity: linking Y-codes with pharmaceutical claims data to identify implicated medicines
Author: Nguyen, T.
Caughey, G.
Pratt, N.
Shakib, S.
Kemp, A.
Roughead, E.
Citation: Journal of Clinical Pharmacy and Therapeutics, 2015; 40(2):213-219
Publisher: Wiley
Issue Date: 2015
ISSN: 0269-4727
1365-2710
Statement of
Responsibility: 
T.A. Nguyen, G. Caughey, N. Pratt, S. Shakib, A. Kemp and E. Roughead
Abstract: WHAT IS KNOWN AND OBJECTIVE: Hospital admissions associated with an adverse drug reaction are often coded to the International Classification of Diseases external cause Y-codes, denoting the medicine class deemed to cause the adverse drug reaction. Matching hospital data with outpatient dispensing data has the potential to identify the specific causative medicines but the ability to identify the causative medicines in this way has not been previously assessed. This study aimed to determine the proportion of Y-coded hospitalizations for drug-induced hepatotoxicity that could be matched with a potential causative medicine from outpatient dispensing data. METHODS: A retrospective cohort study was undertaken from 1 Jan 2005 to 30 June 2012 using data from the Australian Government Department of Veterans’ Affairs of all admissions coded to drug-induced hepatotoxicity. Medicine use in the 6 months prior to hospitalization was examined to identify the probable causative medicines. RESULTS AND DISCUSSION: Thirty five admissions were identified for 31 patients. All admissions were preceded by use of medicines known to cause hepatotoxicity. Twenty four admissions had a Y-code recorded, of which 19 admissions had at least one Y-code specifying the causative medicine class (22 Y-codes). Of the 22 Y-codes, 95% could be successfully matched with a medicine from the same class that had been dispensed in the 6 months prior to admission. Further, 92% were preceded by use of multiple hepatotoxic medicines. WHAT IS NEW AND CONCLUSION: Results of our study demonstrate that hospital administrative data can be linked to prescription dispensing data to identify specific medicines suspected of causing the adverse drug reaction.
Keywords: Adverse event; drug-related; hepatitis; medicine use
Rights: © 2015 John Wiley & Sons Ltd
RMID: 0030033240
DOI: 10.1111/jcpt.12249
Grant ID: http://purl.org/au-research/grants/nhmrc/1040938
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.