Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9510
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Type: Journal article
Title: Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response
Author: Brand, C.
Grimbaldeston, M.
Gamble, J.
Drew, J.
Finlay-Jones, J.
Hart, P.
Citation: Inflammation Research, 2002; 51(5):236-244
Publisher: Birkhauser Verlag Ag
Issue Date: 2002
ISSN: 1023-3830
1420-908X
Statement of
Responsibility: 
C. Brand, M. A. Grimbaldeston, J. R. Gamble, J. Drew, J. J. Finlay-Jones, P. H. Hart
Abstract: <h4>Objective</h4>To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.<h4>Methods</h4>Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten.<h4>Results</h4>TTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNFalpha-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema.<h4>Conclusion</h4>Topical TTO, specifically the TTO components, terpinen-4-ol and alpha-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response.
Keywords: Endothelium, Vascular
Cells, Cultured
Skin
Animals
Mice, Inbred BALB C
Humans
Mice
Dermatitis, Allergic Contact
Edema
Picryl Chloride
Hematoxylin
Eosine Yellowish-(YS)
Tea Tree Oil
Cell Adhesion Molecules
Fluorescent Dyes
Ultraviolet Rays
Coloring Agents
Female
DOI: 10.1007/PL00000299
Appears in Collections:Aurora harvest
Medicine publications

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