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Type: Journal article
Title: Medication regimen complexity and unplanned hospital readmissions in older people
Author: Wimmer, B.
Dent, E.
Bell, J.
Wiese, M.
Chapman, I.
Johnell, K.
Visvanathan, R.
Citation: Annals of Pharmacotherapy, 2014; 48(9):1120-1128
Publisher: SAGE
Issue Date: 2014
ISSN: 1060-0280
Statement of
Barbara C. Wimmer, Elsa Dent, J. Simon Bell, Michael D. Wiese, Ian Chapman, Kristina Johnell, Renuka Visvanathan
Abstract: BACKGROUND: Medication-related problems and adverse drug events are leading causes of preventable hospitalizations. Few previous studies have investigated the possible association between medication regimen complexity and unplanned rehospitalization. OBJECTIVE: To investigate the association between discharge medication regimen complexity and unplanned rehospitalization over a 12-month period. METHOD: The prospective study comprised patients aged ≥70 years old consecutively admitted to a Geriatrics Evaluation and Management (GEM) unit between October 2010 and December 2011. Medication regimen complexity at discharge was calculated using the 65-item validated Medication Regimen Complexity Index (MRCI). Cox proportional-hazards regression was used to compute unadjusted and adjusted hazard ratios (HRs) with 95% CIs for factors associated with rehospitalization over a 12-month follow-up period. RESULT: Of 163 eligible patients, 99 patients had one or more unplanned hospital readmissions. When adjusting for age, sex, activities of daily living, depression, comorbidity, cognitive status, and discharge destination, MRCI (HR = 1.01; 95% CI = 0.81-1.26), number of discharge medications (HR = 1.01; 95% CI = 0.94-1.08), and polypharmacy (≥9 medications; HR = 1.12; 95% CI = 0.69-1.80) were not associated with rehospitalization. In patients discharged to nonhome settings, there was an association between rehospitalization and the number of discharge medications (HR = 1.12; 95% CI = 1.01-1.25) and polypharmacy (HR = 2.24; 95% CI = 1.02-4.94) but not between rehospitalization and MRCI (HR = 1.32; 95% CI = 0.98-1.78). CONCLUSION: Medication regimen complexity was not associated with unplanned hospital readmission in older people. However, in patients discharged to nonhome settings, the number of discharge medications and polypharmacy predicted rehospitalization. A patient's discharge destination is an important factor in unplanned medication-related readmissions.
Keywords: elderly
hospital readmission
medication regimen complexity
Rights: © The Author(s) 2014
DOI: 10.1177/1060028014537469
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