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Type: Journal article
Title: Autophagy as a pro-death pathway
Author: Denton, D.
Xu, T.
Kumar, S.
Citation: Immunology and Cell Biology, 2015; 93(1):35-42
Publisher: Nature Publishing Group
Issue Date: 2015
ISSN: 0818-9641
Statement of
Donna Denton, Tianqi Xu and Sharad Kumar
Abstract: The evolutionarily conserved catabolic process of autophagy involves the degradation of cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain cellular homeostasis and under stress conditions high levels of autophagy are induced. It is often under such stress conditions that high levels of autophagy and cell death have been observed, leading to the idea that autophagy may act as an executioner of cell death. However the notion of autophagy as a cell death mechanism has been controversial and remains mechanistically undefined. There is now growing evidence that in specific contexts autophagy can indeed facilitate cell death. The pro-death role of autophagy is however complicated due to the extensive cross-talk between different signalling pathways. This review summarises the examples of where autophagy acts as a means of cell death and discusses the association of autophagy with the different cell death pathways.
Keywords: Lysosomes
Drosophila melanogaster
Caenorhabditis elegans
Description: Review
Rights: © 2015 Australasian Society for Immunology Inc.
DOI: 10.1038/icb.2014.85
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Appears in Collections:Aurora harvest 3
Medicine publications

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