Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/95592
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Autophagy as a pro-death pathway
Author: Denton, D.
Xu, T.
Kumar, S.
Citation: Immunology and Cell Biology, 2015; 93(1):35-42
Publisher: Nature Publishing Group
Issue Date: 2015
ISSN: 0818-9641
1440-1711
Statement of
Responsibility: 
Donna Denton, Tianqi Xu and Sharad Kumar
Abstract: The evolutionarily conserved catabolic process of autophagy involves the degradation of cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain cellular homeostasis and under stress conditions high levels of autophagy are induced. It is often under such stress conditions that high levels of autophagy and cell death have been observed, leading to the idea that autophagy may act as an executioner of cell death. However the notion of autophagy as a cell death mechanism has been controversial and remains mechanistically undefined. There is now growing evidence that in specific contexts autophagy can indeed facilitate cell death. The pro-death role of autophagy is however complicated due to the extensive cross-talk between different signalling pathways. This review summarises the examples of where autophagy acts as a means of cell death and discusses the association of autophagy with the different cell death pathways.
Keywords: Lysosomes
Phagosomes
Drosophila melanogaster
Caenorhabditis elegans
Dictyostelium
Description: Review
Rights: © 2015 Australasian Society for Immunology Inc.
DOI: 10.1038/icb.2014.85
Grant ID: http://purl.org/au-research/grants/nhmrc/1041807
http://purl.org/au-research/grants/nhmrc/1002863
Appears in Collections:Aurora harvest 3
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.