Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Autophagy as a pro-death pathway|
|Citation:||Immunology and Cell Biology, 2015; 93(1):35-42|
|Publisher:||Nature Publishing Group|
|Donna Denton, Tianqi Xu and Sharad Kumar|
|Abstract:||The evolutionarily conserved catabolic process of autophagy involves the degradation of cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain cellular homeostasis and under stress conditions high levels of autophagy are induced. It is often under such stress conditions that high levels of autophagy and cell death have been observed, leading to the idea that autophagy may act as an executioner of cell death. However the notion of autophagy as a cell death mechanism has been controversial and remains mechanistically undefined. There is now growing evidence that in specific contexts autophagy can indeed facilitate cell death. The pro-death role of autophagy is however complicated due to the extensive cross-talk between different signalling pathways. This review summarises the examples of where autophagy acts as a means of cell death and discusses the association of autophagy with the different cell death pathways.|
|Rights:||© 2015 Australasian Society for Immunology Inc.|
|Appears in Collections:||Aurora harvest 3|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.