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Type: Journal article
Title: Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
Author: Hu, Y.
Zhou, H.
Myers, D.
Quinn, J.
Atkins, G.
Ly, C.
Gange, C.
Kartsogiannis, V.
Elliott, J.
Kostakis, P.
Zannettino, A.
Cromer, B.
McKinstry, W.
Findlay, D.
Gillespie, M.
Ng, K.
Citation: Journal of Bone and Mineral Research, 2004; 19(1):89-99
Publisher: Amer Soc Bone & Mineral Res
Issue Date: 2004
ISSN: 0884-0431
Statement of
Yun Shan Hu, Hong Zhou, Damian Myers, Julian M W Quinn, Gerald J Atkins, Chi Ly, Christine Gange, Vicky Kartsogiannis, Jan Elliott, Panagiota Kostakis, Andrew Cw Zannettino, Brett Cromer, William J Mckinstry, David M Findlay, Matthew T Gillespie, Kong Wah Ng
Abstract: Osteoclast inhibitory lectin (OCIL) is a newly recognized inhibitor of osteoclast formation. We identified a human homolog of OCIL and its gene, determined its regulation in human osteoblast cell lines, and established that it can inhibit murine and human osteoclast formation and resorption. OCIL shows promise as a new antiresorptive.
Keywords: osteoclasts
C-type lectin
natural killer cell receptors
natural killer gene complex
bone resorption
Description: Copyright © by the American Society for Bone and Mineral Research. Published versions of the genetic sequence discussed by the authors are available via the description links below.
DOI: 10.1359/jbmr.0301215
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