Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9567
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Type: Journal article
Title: The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)
Author: Pan, B.
Farrugia, A.
To, L.
Findlay, D.
Green, J.
Lynch, K.
Zannettino, A.
Citation: Journal of Bone and Mineral Research, 2004; 19(1):147-154
Publisher: Amer Soc Bone & Mineral Res
Issue Date: 2004
ISSN: 0884-0431
1523-4681
Statement of
Responsibility: 
Beiqing Pan, Amanda N Farrugia, Luen Bik To, David M Findlay, Jonathan Green, Kevin Lynch, Andrew CW Zannettino
Abstract: Bisphosphonates are used to prevent osteoclast-mediated bone loss. Zoledronic acid inhibits osteoclast maturation indirectly by increasing OPG protein secretion and decreasing transmembrane RANKL expression in human osteoblasts. The decreased transmembrane RANKL expression seems to be related to the upregulation of the RANKL sheddase, TACE.
Keywords: Cells, Cultured; Osteoblasts; Humans; Hydroxamic Acids; Diphosphonates; Imidazoles; Metalloendopeptidases; Carrier Proteins; Membrane Glycoproteins; Receptors, Tumor Necrosis Factor; Blotting, Western; Flow Cytometry; Immunohistochemistry; Gene Expression; ADAM Proteins; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Osteoprotegerin; ADAM17 Protein
Description: © American Society for Bone and Mineral Research.
RMID: 0020040089
DOI: 10.1359/jbmr.2004.19.1.147
Appears in Collections:Medicine publications

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