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Type: Journal article
Title: The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)
Author: Pan, B.
Farrugia, A.
To, L.
Findlay, D.
Green, J.
Lynch, K.
Zannettino, A.
Citation: Journal of Bone and Mineral Research, 2004; 19(1):147-154
Publisher: Amer Soc Bone & Mineral Res
Issue Date: 2004
ISSN: 0884-0431
Statement of
Beiqing Pan, Amanda N Farrugia, Luen Bik To, David M Findlay, Jonathan Green, Kevin Lynch, Andrew CW Zannettino
Abstract: Bisphosphonates are used to prevent osteoclast-mediated bone loss. Zoledronic acid inhibits osteoclast maturation indirectly by increasing OPG protein secretion and decreasing transmembrane RANKL expression in human osteoblasts. The decreased transmembrane RANKL expression seems to be related to the upregulation of the RANKL sheddase, TACE.
Keywords: Cells, Cultured
Hydroxamic Acids
Carrier Proteins
Membrane Glycoproteins
Receptors, Tumor Necrosis Factor
Blotting, Western
Flow Cytometry
Gene Expression
ADAM Proteins
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
ADAM17 Protein
Zoledronic Acid
Description: © American Society for Bone and Mineral Research.
DOI: 10.1359/jbmr.2004.19.1.147
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