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dc.contributor.authorTrovato, A.en
dc.contributor.authorPanelli, S.en
dc.contributor.authorStrozzi, F.en
dc.contributor.authorCambulli, C.en
dc.contributor.authorBarbieri, I.en
dc.contributor.authorMartinelli, N.en
dc.contributor.authorLombardi, G.en
dc.contributor.authorCapoferri, R.en
dc.contributor.authorWilliams, J.en
dc.identifier.citationBMC Veterinary Research, 2015; 11(1):105-1-105-9en
dc.description.abstractBACKGROUND: Bovine Amyloidotic Spongiform Encephalopathy (BASE) is a variant of classical BSE that affects cows and can be transmitted to primates and mice. BASE is biochemically different from BSE and shares some molecular and histo-pathological features with the MV2 sub-type of human sporadic Creutzfeld Jakob Disease (sCJD). RESULTS: The present work examined the effects of BASE on gene expression in circulating immune cells. Ontology analysis of genes differentially expressed between cattle orally challenged with brain homogenate from cattle following intracranial inoculation with BASE and control cattle identified three main pathways which were affected. Within the immune function pathway, the most affected genes were related to the T cell receptor-mediated T cell activation pathways. The differential expression of these genes in BASE challenged animals at 10,12 and 24 months following challenge, vs unchallenged controls, was investigated by real time PCR. CONCLUSIONS: The results of this study show that the effects of prion diseases are not limited to the CNS, but involve the immune system and particularly T cell signalling during the early stage following challenge, before the appearance of clinical signs.en
dc.description.statementofresponsibilityAndrea Trovato, Simona Panelli, Francesco Strozzi, Caterina Cambulli, Ilaria Barbieri, Nicola Martinelli, Guerino Lombardi, Rossana Capoferri and John L Williamsen
dc.publisherBiomed Centralen
dc.rights© 2015 Trovato et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectBovine Amyloidotic Spongiform Encephalopathy (BASE); Transmissible Spongiform Encephalopathies (TSEs); Immune function; Cattleen
dc.titleExpression of genes involved in the T cell signalling pathway in circulating immune cells of cattle 24 months following oral challenge with Bovine Amyloidotic Spongiform Encephalopathy (BASE)en
dc.typeJournal articleen
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
dc.identifier.orcidWilliams, J. [0000-0001-5188-7957]en
Appears in Collections:Animal and Veterinary Sciences publications

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