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Type: Journal article
Title: Gamma-irradiated influenza A virus provides adjuvant activity to a co-administered poorly immunogenic SFV vaccine in mice
Author: Babb, R.
Chan, J.
Khairat, J.
Furuya, Y.
Alsharifi, M.
Citation: Frontiers in Immunology, 2014; 5(Jun):267-1-267-7
Publisher: Frontiers Research Foundation
Issue Date: 2014
ISSN: 1664-3224
Statement of
Rachelle Babb, Jennifer Chan, Jasmine E. Khairat, Yoichi Furuya and Mohammed Alsharifi
Abstract: Many currently available inactivated vaccines require "adjuvants" to maximize the protective immune responses generated against the antigens of interest. Recent studies in mice with gamma-irradiated influenza A virus (γ-FLU) have shown its superior efficacy compared to other forms of inactivated FLU vaccines and its ability to induce both potent interferon type-I (IFN-I) responses and the IFN-I-associated partial lymphocyte activation. Commonly, IFN-I responses induced by adjuvants, combined in vaccine preparations, have been shown to effectively enhance the immunogenicity of the antigens of interest. Therefore, we investigated the potential adjuvant activity of γ-FLU and the possible effect on antibody responses against co-administrated antigens, using gamma-irradiated Semliki Forest virus (γ-SFV) as the experimental vaccine in mice. Our data show that co-vaccination with γ-FLU and γ-SFV resulted in enhanced SFV-specific antibody responses in terms of increased titers by sixfold and greater neutralization efficacy, when compared to vaccination with γ-SFV alone. This study provides promising evidence related to the possible use of γ-FLU as an adjuvant to poorly immunogenic vaccines without compromising the vaccine efficacy of γ-FLU.
Keywords: adjuvants; antibodies; combined vaccine; gamma-irradiation; influenza vaccines
Rights: © 2014 Babb, Chan, Khairat, Furuya and Alsharifi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030013297
DOI: 10.3389/fimmu.2014.00267
Appears in Collections:Molecular and Biomedical Science publications

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