Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Hormone Molecular Biology and Clinical Investigation, 2014; 20(1):3-13||-|
|dc.description.abstract||In diet induced and genetically obese rodent models, adipose tissue is associated with macrophage infiltration, which promotes a low grade inflammatory state and the development of insulin resistance. In humans, obesity is also closely linked with macrophage infiltration in adipose tissue, a pro-inflammatory phenotype and insulin resistance. However, whether macrophage infiltration is a direct contributor to the development of insulin resistance that occurs in response to weight gain, or is a later consequence of the obese state is unclear. There are a number of concomitant changes that occur during adipose tissue expansion, including the number and size of adipocytes, the vasculature and the extracellular matrix. In this review, we will examine evidence for and against the role of macrophage recruitment into adipose tissue in promoting the development of insulin resistance in rodents and humans, as well as discuss the emerging role of macrophages in mediating healthy adipose tissue expansion during periods of caloric excess.||-|
|dc.description.statementofresponsibility||Leonie K. Heilbronn and Bo Liu||-|
|dc.rights||Copyright of Hormone Molecular Biology & Clinical Investigation is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.||-|
|dc.subject||Adipose tissue remodelling; inflammation; insulin resistance; macrophages; obesity||-|
|dc.title||Do adipose tissue macrophages promote insulin resistance or adipose tissue remodelling in humans?||-|
|dc.identifier.orcid||Heilbronn, L. [0000-0003-2106-7303]||-|
|dc.identifier.orcid||Liu, B. [0000-0003-3101-650X]||-|
|Appears in Collections:||Aurora harvest 7|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.