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https://hdl.handle.net/2440/9584
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dc.contributor.author | Pilichiewicz, A. | - |
dc.contributor.author | O'Donovan, D. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Lei, Y. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Bryant, L. | - |
dc.contributor.author | Meyer, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Jones, K. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2003; 88(8):3829-3834 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9584 | - |
dc.description.abstract | This study examined the effects of the lipase inhibitor, orlistat, on gastric emptying of, and the glycemic and incretin hormone responses to, a drink containing oil and glucose components in patients with type 2 diabetes. Seven patients (aged 58 +/- 5 yr), managed by diet alone, consumed 60 ml olive oil (labeled with 20 MBq (99m)Tc-V-thiocyanate) and 300 ml water containing 75 g glucose (labeled with 6 MBq (67)Ga-EDTA), on two occasions, with and without 120 mg orlistat, positioned in the left lateral decubitus position with their back against a gamma camera. Venous blood samples, for measurement of blood glucose and plasma insulin, glucagon-like peptide-1 and glucose-dependent insulintropic polypeptide were obtained immediately before, and after, the drink. Gastric emptying of both oil (P < 0.001) and glucose (P < 0.0005) was faster after orlistat compared with control. Postprandial blood glucose (P < 0.001) and plasma insulin (P < 0.05) were substantially greater after orlistat compared with control. In contrast, plasma glucagon-like peptide-1 (P < 0.005) and glucose-dependent insulintropic polypeptide (P < 0.05) were less after orlistat. In conclusion, inhibition of fat digestion, by orlistat, may exacerbate postprandial glycemia, as a result of more rapid gastric emptying and a diminished incretin response. | - |
dc.description.statementofresponsibility | A. Pilichiewicz, D. O’Donovan, C. Feinle, Y. Lei, J. M. Wishart, L. Bryant, J. H. Meyer, M. Horowitz, and K. L. Jones | - |
dc.language.iso | en | - |
dc.publisher | Endocrine Society | - |
dc.rights | © 2003 by The Endocrine Society | - |
dc.source.uri | http://jcem.endojournals.org/cgi/content/abstract/88/8/3829 | - |
dc.subject | Gastric Mucosa | - |
dc.subject | Autonomic Nervous System | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Lactones | - |
dc.subject | Gastric Inhibitory Polypeptide | - |
dc.subject | Glucagon | - |
dc.subject | Insulin | - |
dc.subject | Lipase | - |
dc.subject | Glucose | - |
dc.subject | Blood Glucose | - |
dc.subject | Dietary Fats | - |
dc.subject | Peptides | - |
dc.subject | Peptide Fragments | - |
dc.subject | Enzyme Inhibitors | - |
dc.subject | Gastric Emptying | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.subject | Glucagon-Like Peptides | - |
dc.subject | Hemodynamics | - |
dc.subject | Orlistat | - |
dc.title | Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2003-030199 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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