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dc.contributor.authorPilichiewicz, A.en
dc.contributor.authorO'Donovan, D.en
dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorLei, Y.en
dc.contributor.authorWishart, J.en
dc.contributor.authorBryant, L.en
dc.contributor.authorMeyer, J.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2003; 88(8):3829-3834en
dc.description.abstractThis study examined the effects of the lipase inhibitor, orlistat, on gastric emptying of, and the glycemic and incretin hormone responses to, a drink containing oil and glucose components in patients with type 2 diabetes. Seven patients (aged 58 +/- 5 yr), managed by diet alone, consumed 60 ml olive oil (labeled with 20 MBq (99m)Tc-V-thiocyanate) and 300 ml water containing 75 g glucose (labeled with 6 MBq (67)Ga-EDTA), on two occasions, with and without 120 mg orlistat, positioned in the left lateral decubitus position with their back against a gamma camera. Venous blood samples, for measurement of blood glucose and plasma insulin, glucagon-like peptide-1 and glucose-dependent insulintropic polypeptide were obtained immediately before, and after, the drink. Gastric emptying of both oil (P < 0.001) and glucose (P < 0.0005) was faster after orlistat compared with control. Postprandial blood glucose (P < 0.001) and plasma insulin (P < 0.05) were substantially greater after orlistat compared with control. In contrast, plasma glucagon-like peptide-1 (P < 0.005) and glucose-dependent insulintropic polypeptide (P < 0.05) were less after orlistat. In conclusion, inhibition of fat digestion, by orlistat, may exacerbate postprandial glycemia, as a result of more rapid gastric emptying and a diminished incretin response.en
dc.description.statementofresponsibilityA. Pilichiewicz, D. O’Donovan, C. Feinle, Y. Lei, J. M. Wishart, L. Bryant, J. H. Meyer, M. Horowitz, and K. L. Jonesen
dc.publisherEndocrine Societyen
dc.rights© 2003 by The Endocrine Societyen
dc.subjectStomach; Autonomic Nervous System; Humans; Diabetes Mellitus, Type 2; Lactones; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Lipase; Glucose; Blood Glucose; Dietary Fats; Peptides; Peptide Fragments; Enzyme Inhibitors; Gastric Emptying; Middle Aged; Female; Male; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hemodynamicsen
dc.titleEffect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitusen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
Appears in Collections:Medicine publications

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