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https://hdl.handle.net/2440/9585
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Type: | Journal article |
Title: | Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome |
Author: | Moran, L. Noakes, M. Clifton, P. Tomlinson, L. Norman, R. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2003; 88(2):812-819 |
Publisher: | Endocrine Society |
Issue Date: | 2003 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | L. J. Moran, M. Noakes, P. M. Clifton, L. Tomlinson and R. J. Norman |
Abstract: | Overweight women with polycystic ovary syndrome (PCOS) were randomized to a high protein (HP; 40% carbohydrate and 30% protein; n = 14) or a low protein (LP; 55% carbohydrate and 15% protein) diet (n = 14). The intervention consisted of 12 wk of energy restriction (approximately 6000 kJ/d), followed by 4 wk of weight maintenance. Pregnancies (two HP and one LP); improvements in menstrual cyclicity, lipid profile, and insulin resistance (as measured by the homeostasis model); and decreases in weight (7.5%) and abdominal fat (12.5%) occurred independently of diet composition. Improvements in menstrual cyclicity were associated with greater decreases in insulin resistance and fasting insulin (P = 0.011). On the LP diet, high density lipoprotein cholesterol decreased 10% during energy restriction (P = 0.008), and the free androgen index increased 44% in weight maintenance stages (P = 0.027). Weight loss leads to improvements in cardiovascular and reproductive parameters potentially mediated by improvements in surrogate measures of insulin resistance. An HP weight loss diet may result in minor differential endocrine and metabolic improvements. |
Keywords: | Humans Polycystic Ovary Syndrome Hirsutism Obesity Weight Loss Testosterone Insulin Dietary Carbohydrates Blood Glucose Lipids Sex Hormone-Binding Globulin Dietary Proteins Exercise Diet, Protein-Restricted Body Composition Energy Metabolism Ovulation Pregnancy Adult Female |
Description: | Copyright © 2003 by The Endocrine Society |
DOI: | 10.1210/jc.2002-020815 |
Published version: | http://jcem.endojournals.org/cgi/content/abstract/88/2/812 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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