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dc.contributor.authorPaynter, S.en
dc.contributor.authorWare, R.en
dc.contributor.authorLucero, M.en
dc.contributor.authorTallo, V.en
dc.contributor.authorNohynek, H.en
dc.contributor.authorWeinstein, P.en
dc.contributor.authorWilliams, G.en
dc.contributor.authorSly, P.en
dc.contributor.authorSimoes, E.en
dc.identifier.citationPediatric Infectious Disease Journal, 2014; 33(3):267-271en
dc.description.abstractBACKGROUND: Longitudinal information examining the effect of poor infant growth on respiratory syncytial virus (RSV) severity is limited. Children hospitalized with RSV lower respiratory infection represent those at the severe end of the disease spectrum. METHODS: We followed up a cohort of 12,191 infants enrolled in a previous pneumococcal vaccine trial in Bohol, Philippines. Exposure measures were weight for age z-score at the first vaccination visit (median age 1.8 months) as well as the growth (the difference in weight for age z-score) between the first and third vaccination visits. The outcome was hospitalization with RSV lower respiratory infection. RESULTS: Children with a weight for age z-score ≤ -2 at their first vaccination visit had the highest rate of hospitalization with RSV lower respiratory infection, but this association was only evident in children whose mothers had >10 years of education (hazard ratio: 3.38; 95% confidence interval: 1.63-6.98). Children who had lower than median growth between their first and third vaccinations had a higher rate of RSV-associated hospitalization than those with growth above the median (hazard ratio: 1.34; 95% confidence interval: 1.02-1.76). CONCLUSIONS: Poor infant growth increases the risk for severe RSV infection leading to hospitalization.en
dc.description.statementofresponsibilityStuart Paynter, Robert S. Ware, Marilla G. Lucero, Veronica Tallo, Hannah Nohynek, Philip Weinstein, Gail Williams, Peter D. Sly and Eric A. F. Simõesen
dc.publisherLippincott, Williams & Wilkinsen
dc.rights© 2014 by Lippincott Williams & Wilkins, Inc.en
dc.subjectepidemiology; nutrition; cohort studyen
dc.titleMalnutrition: a risk factor for severe respiratory syncytial virus infection and hospitalizationen
dc.typeJournal articleen
pubs.library.collectionPublic Health publicationsen
Appears in Collections:Public Health publications

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